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Authors
Karasaki, Takahiro https://orcid.org/0000-0001-6863-2360
Moore, David A. https://orcid.org/0000-0002-6296-1312
Veeriah, Selvaraju
Naceur-Lombardelli, Cristina
Toncheva, Antonia
Magno, Neil
Ward, Sophia https://orcid.org/0000-0002-6777-5279
Bakir, Maise Al https://orcid.org/0000-0002-0846-8332
Watkins, Thomas B. K.
Grigoriadis, Kristiana https://orcid.org/0000-0002-8435-0176
Huebner, Ariana https://orcid.org/0000-0001-8009-4999
Hill, Mark S. https://orcid.org/0000-0003-0718-8934
Frankell, Alexander M. https://orcid.org/0000-0002-0341-7878
Abbosh, Christopher https://orcid.org/0000-0002-8983-1382
Puttick, Clare
Zhai, Haoran
Gimeno-Valiente, Francisco
Saghafinia, Sadegh
Kanu, Nnennaya
Dietzen, Michelle https://orcid.org/0000-0002-6853-7563
Pich, Oriol https://orcid.org/0000-0002-1956-1882
Lim, Emilia L.
Martínez-Ruiz, Carlos https://orcid.org/0000-0002-4817-0565
Black, James R. M.
Biswas, Dhruva https://orcid.org/0000-0001-9141-5188
Campbell, Brittany B.
Lee, Claudia https://orcid.org/0000-0003-1715-2265
Colliver, Emma https://orcid.org/0000-0002-1497-0740
Enfield, Katey S. S. https://orcid.org/0000-0002-4551-6073
Hessey, Sonya https://orcid.org/0000-0001-9856-424X
Hiley, Crispin T.
Zaccaria, Simone https://orcid.org/0000-0002-5265-7392
Litchfield, Kevin
Birkbak, Nicolai J. https://orcid.org/0000-0003-1613-9587
Cadieux, Elizabeth Larose
Demeulemeester, Jonas https://orcid.org/0000-0002-2660-2478
Van Loo, Peter https://orcid.org/0000-0003-0292-1949
Adusumilli, Prasad S. https://orcid.org/0000-0002-1699-2046
Tan, Kay See
Cheema, Waseem https://orcid.org/0000-0002-8000-7493
Sanchez-Vega, Francisco https://orcid.org/0000-0002-2990-4893
Jones, David R. https://orcid.org/0000-0002-3318-0146
Rekhtman, Natasha
Travis, William D.
Hackshaw, Allan https://orcid.org/0000-0002-5570-5070
Marafioti, Teresa
Salgado, Roberto https://orcid.org/0000-0002-1110-3801
Le Quesne, John https://orcid.org/0000-0003-3552-7446
Nicholson, Andrew G.
,
Van Loo, Peter
Le Quesne, John
Lester, Jason F.
Bajaj, Amrita
Nakas, Apostolos
Sodha-Ramdeen, Azmina
Ang, Keng
Tufail, Mohamad
Chowdhry, Mohammed Fiyaz
Scotland, Molly
Boyles, Rebecca
Rathinam, Sridhar
Wilson, Claire
Marrone, Domenic
Dulloo, Sean
Fennell, Dean A.
Matharu, Gurdeep
Shaw, Jacqui A.
Riley, Joan
Primrose, Lindsay
Boleti, Ekaterini
Cheyne, Heather
Khalil, Mohammed
Richardson, Shirley
Cruickshank, Tracey
Price, Gillian
Kerr, Keith M.
Benafif, Sarah
Gilbert, Kayleigh
Naidu, Babu
Patel, Akshay J.
Osman, Aya
Lacson, Christer
Langman, Gerald
Shackleford, Helen
Djearaman, Madava
Kadiri, Salma
Middleton, Gary
Leek, Angela
Hodgkinson, Jack Davies
Totten, Nicola
Montero, Angeles
Smith, Elaine
Fontaine, Eustace
Granato, Felice
Doran, Helen
Novasio, Juliette
Rammohan, Kendadai
Joseph, Leena
Bishop, Paul
Shah, Rajesh
Moss, Stuart
Joshi, Vijay
Crosbie, Philip
Gomes, Fabio
Brown, Kate
Carter, Mathew
Chaturvedi, Anshuman
Priest, Lynsey
Oliveira, Pedro
Lindsay, Colin R.
Blackhall, Fiona H.
Krebs, Matthew G.
Summers, Yvonne
Clipson, Alexandra
Tugwood, Jonathan
Kerr, Alastair
Rothwell, Dominic G.
Kilgour, Elaine
Dive, Caroline
Aerts, Hugo J. W. L.
Schwarz, Roland F.
Kaufmann, Tom L.
Wilson, Gareth A.
Rosenthal, Rachel
Szallasi, Zoltan
Kisistok, Judit
Sokac, Mateo
Diossy, Miklos
Bunkum, Abigail
Stewart, Aengus
Magness, Alastair
Rowan, Andrew
Karamani, Angeliki
Chain, Benny
Castignani, Carla
Bailey, Chris
Weeden, Clare E.
Richard, Corentin
Pearce, David R.
Karagianni, Despoina
Levi, Dina
Hoxha, Elena
Nye, Emma
Grönroos, Eva
Gálvez-Cancino, Felip
Athanasopoulou, Foteini
Kassiotis, George
Stavrou, Georgia
Mastrokalos, Gerasimos
Lowe, Helen L.
Matos, Ignacio Garcia
Goldman, Jacki
Reading, James L.
Herrero, Javier
Rane, Jayant K.
Nicod, Jerome
Lam, Jie Min
Hartley, John A.
Peggs, Karl S.
Selvaraju, Kayalvizhi
Thol, Kerstin
Ng, Kevin W.
Chen, Kezhong
Dijkstra, Krijn
Thakkar, Krupa
Ensell, Leah
Shah, Mansi
Duran, Marcos Vasquez
Litovchenko, Maria
Sunderland, Mariana Werner
Leung, Michelle
Escudero, Mickael
Angelova, Mihaela
Tanić, Miljana
Sivakumar, Monica
Chervova, Olga
Lucas, Olivia
Al-Sawaf, Othman
Prymas, Paulina
Hobson, Philip
Pawlik, Piotr
Stone, Richard Kevin
Bentham, Robert
Hynds, Robert E.
Vendramin, Roberto
López, Saioa
Gamble, Samuel
Ung, Seng Kuong Anakin
Quezada, Sergio A.
Vanloo, Sharon
Boeing, Stefan
Beck, Stephan
Bola, Supreet Kaur
Denner, Tamara
Mourikis, Thanos P.
Spanswick, Victoria
Barbè, Vittorio
Lu, Wei-Ting
Hill, William
Liu, Wing Kin
Wu, Yin
Naito, Yutaka
Ramsden, Zoe
Veiga, Catarina
Royle, Gary
Collins-Fekete, Charles-Antoine
Fraioli, Francesco
Ashford, Paul
Clark, Tristan
Forster, Martin D.
Lee, Siow Ming
Borg, Elaine
Falzon, Mary
Papadatos-Pastos, Dionysis
Wilson, James
Ahmad, Tanya
Procter, Alexander James
Ahmed, Asia
Taylor, Magali N.
Nair, Arjun
Lawrence, David
Patrini, Davide
Navani, Neal
Thakrar, Ricky M.
Janes, Sam M.
Hoogenboom, Emilie Martinoni
Monk, Fleur
Holding, James W.
Choudhary, Junaid
Bhakhri, Kunal
Scarci, Marco
Hayward, Martin
Panagiotopoulos, Nikolaos
Gorman, Pat
Khiroya, Reena
Stephens, Robert CM.
Wong, Yien Ning Sophia
Bandula, Steve
Sharp, Abigail
Smith, Sean
Gower, Nicole
Dhanda, Harjot Kaur
Chan, Kitty
Pilotti, Camilla
Leslie, Rachel
Grapa, Anca
Zhang, Hanyun
AbdulJabbar, Khalid
Pan, Xiaoxi
Yuan, Yinyin
Chuter, David
MacKenzie, Mairead
Chee, Serena
Alzetani, Aiman
Cave, Judith
Scarlett, Lydia
Richards, Jennifer
Ingram, Papawadee
Austin, Silvia
Lim, Eric
De Sousa, Paulo
Jordan, Simon
Rice, Alexandra
Raubenheimer, Hilgardt
Bhayani, Harshil
Ambrose, Lyn
Devaraj, Anand
Chavan, Hema
Begum, Sofina
Buderi, Silviu I.
Kaniu, Daniel
Malima, Mpho
Booth, Sarah
Fernandes, Nadia
Shah, Pratibha
Proli, Chiara
Hewish, Madeleine
Danson, Sarah
Shackcloth, Michael J.
Robinson, Lily
Russell, Peter
Blyth, Kevin G.
Dick, Craig
Kirk, Alan
Asif, Mo
Bilancia, Rocco
Kostoulas, Nikos
Thomas, Mathew
McGranahan, Nicholas https://orcid.org/0000-0001-9537-4045
Swanton, Charles https://orcid.org/0000-0002-4299-3018
Jamal-Hanjani, Mariam https://orcid.org/0000-0003-1212-1259
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Article History
Received: 26 April 2022
Accepted: 24 January 2023
First Online: 12 April 2023
Competing interests
: D.A.M. reports speaker fees from AstraZeneca, Eli Lilly and Takeda, consultancy fees from AstraZeneca, Thermo Fisher, Takeda, Amgen, Janssen, MIM Software, Bristol Myers Squibb (BMS) and Eli Lilly and has received educational support from Takeda and Amgen. S.V. is a co-inventor to a patent for detecting molecules in a sample (US patent no. 10578620). M.A.B. has consulted for Achilles Therapeutics. A.M.F. is co-inventor to a patent application to determine methods and systems for tumor monitoring (PCT/EP2022/077987). C.A. has received speaking honoraria or expenses from Novartis, Roche, AstraZeneca and Bristol Myers Squibb and reports employment at AstraZeneca. C.A. is an inventor on a European patent application relating to assay technology to detect tumor recurrence (PCT/GB2017/053289), the patent has been licensed to commercial entities and under their terms of employment C.A. is due a revenue share of any revenue generated from such license(s). C.A. declares a patent application (PCT/US2017/028013) for methods to detect lung cancer. C.A. is a named inventor on a patent application to determine methods and systems for tumor monitoring (PCT/EP2022/077987) and is a named inventor on a provisional patent protection related to a ctDNA detection algorithm. D.B. reports personal fees from NanoString and AstraZeneca, and has a patent PCT/GB2020/050221 issued on methods for cancer prognostication. K.S.S.E. received research grant funding from BMS. C.T.H. has received speaker fees from AstraZeneca. K.L. has a patent on indel burden and CPI response pending and speaker fees from Roche tissue diagnostics, research funding from CRUK TDL/Ono/LifeArc alliance, Genesis Therapeutics, and consulting roles with Monopteros Therapeutics and Kynos Therapeutics. N.J.B. is a co-inventor to a patent for identification of responders to cancer treatment (PCT/GB2018/051912), has a patent application (PCT/GB2020/050221) on methods for cancer prognostication and a patent on methods for predicting anti-cancer response (US14/466,208). E.L.C. is employed by and holds shares in Achilles Therapeutics. P.S.A. is a Scientific Advisory Board Member and Consultant for ATARA Biotherapeutics, Bayer, Carisma Therapeutics, Imugene, ImmPactBio, Johnston & Johnston, Orion and OutpaceBio; declares patents, royalties and intellectual property on mesothelin-targeted CARs and other T cell therapies, which have been licensed to ATARA Biotherapeutics, issued patent method for detection of cancer cells using virus, and pending patent applications on PD-1 dominant negative receptor, wireless pulse-oximetry device, and on an ex vivo malignant pleural effusion culture system. Memorial Sloan Kettering Cancer Center (MSK) has licensed intellectual property related to mesothelin-targeted CARs and T-cell therapies to ATARA Biotherapeutics, and has associated royalties. D.R.J. has consulted for AstraZeneca, is a member of Clinical Trial Steering Committee for Merck, is a speaker for DAVA Oncology and is a member of the NCI Board of Scientific Advisors. N.R. has served on the Advisory Board for Merck, and is a member of the NCI Thoracic Malignancies Steering Committee. W.D.T. is a non-paid consultant for the LCMC3 and LCMC4 neoadjuvant clinical trials. A. Hackshaw has received fees for being a member of Independent Data Monitoring Committees for Roche-sponsored clinical trials, and academic projects coordinated by Roche. R.S. reports nonfinancial support from Merck and BMS, research support from Merck, Puma Biotechnology and Roche, and personal fees from Roche, BMS and Exact Sciences for advisory boards. A.G.N. reports personal fees from Merck, Boehringer Ingelheim, Novartis, AstraZeneca, BMS, Roche, Abbvie, Oncologica, Uptodate, European Society of Oncology, Takeda UK and Liberium, and personal fees and grants from Pfizer. N.M. has stock options in and has consulted for Achilles Therapeutics and holds European patents relating to targeting neoantigens (PCT/EP2016/ 059401), identifying patient response to immune checkpoint blockade (PCT/ EP2016/071471), determining HLA LOH (PCT/GB2018/052004) and predicting survival rates of patients with cancer (PCT/GB2020/050221). M.J.-H. has consulted for, and is a member of, the Achilles Therapeutics Scientific Advisory Board and Steering Committee, has received speaker honoraria from Pfizer, Astex Pharmaceuticals and Oslo Cancer Cluster, and is co-inventor on a European patent application relating to methods to detect lung cancer (PCT/US2017/028013). This patent has been licensed to commercial entities and under terms of employment M.J.-H. is due a share of any revenue generated from such license(s). C.S. acknowledges grant support from AstraZeneca, Boehringer Ingelheim, BMS, Pfizer, Roche-Ventana, Invitae (previously Archer Dx—collaboration in minimal residual disease sequencing technologies) and Ono Pharmaceutical. C.S. is an AstraZeneca Advisory Board member and Chief Investigator for the AZ MeRmaiD 1 and 2 clinical trials and is also co-chief investigator of the NHS Galleri trial funded by GRAIL and a paid member of GRAIL’s Scientific Advisory Board. C.S. receives consultant fees from Achilles Therapeutics (also SAB member), Bicycle Therapeutics (also a SAB member), Genentech, Medicxi, Roche Innovation Centre – Shanghai, Metabomed (until July 2022) and the Sarah Cannon Research Institute. C.S. had stock options in Apogen Biotechnologies and GRAIL until June 2021, and currently has stock options in Epic Bioscience, Bicycle Therapeutics, and has stock options in and is co-founder of Achilles Therapeutics. C.S. is an inventor on a European patent application relating to assay technology to detect tumor recurrence (PCT/GB2017/053289); the patent has been licensed to commercial entities and under terms of employment C.S. is due a revenue share of any revenue generated from such license(s). C.S. holds patents relating to targeting neoantigens (PCT/EP2016/059401), identifying patient response to immune checkpoint blockade (PCT/EP2016/071471), determining HLA LOH (PCT/GB2018/052004), predicting survival rates of patients with cancer (PCT/GB2020/050221), identifying patients who respond to cancer treatment (PCT/GB2018/051912), US patent relating to detecting tumor mutations (PCT/US2017/28013), methods for lung cancer detection (US20190106751A1) and both a European and US patent related to identifying insertion/deletion mutation targets (PCT/GB2018/051892). C.S. is a co-inventor to a patent application to determine methods and systems for tumor monitoring (PCT/EP2022/077987) and is a named inventor on a provisional patent protection related to a ctDNA detection algorithm. The other authors declare no competing interests.
