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Authors
Al-Sawaf, Othman http://orcid.org/0000-0001-9895-0570
Weiss, Jakob
Skrzypski, Marcin
Lam, Jie Min http://orcid.org/0000-0001-9523-5029
Karasaki, Takahiro http://orcid.org/0000-0001-6863-2360
Zambrana, Francisco
Kidd, Andrew C.
Frankell, Alexander M. http://orcid.org/0000-0002-0341-7878
Watkins, Thomas B. K.
Martínez-Ruiz, Carlos http://orcid.org/0000-0002-4817-0565
Puttick, Clare
Black, James R. M.
Huebner, Ariana http://orcid.org/0000-0001-8009-4999
Bakir, Maise Al http://orcid.org/0000-0002-0846-8332
Sokač, Mateo
Collins, Susie
Veeriah, Selvaraju
Magno, Neil
Naceur-Lombardelli, Cristina
Prymas, Paulina
Toncheva, Antonia
Ward, Sophia http://orcid.org/0000-0002-6777-5279
Jayanth, Nick
Salgado, Roberto http://orcid.org/0000-0002-1110-3801
Bridge, Christopher P. http://orcid.org/0000-0002-2242-351X
Christiani, David C. http://orcid.org/0000-0002-0301-0242
Mak, Raymond H. http://orcid.org/0000-0002-8754-0565
Bay, Camden
Rosenthal, Michael
Sattar, Naveed
Welsh, Paul http://orcid.org/0000-0002-7970-3643
Liu, Ying http://orcid.org/0000-0002-6419-1980
Perrimon, Norbert http://orcid.org/0000-0001-7542-472X
Popuri, Karteek
Beg, Mirza Faisal
McGranahan, Nicholas
Hackshaw, Allan http://orcid.org/0000-0002-5570-5070
Breen, Danna M.
O’Rahilly, Stephen http://orcid.org/0000-0003-2199-4449
Birkbak, Nicolai J. http://orcid.org/0000-0003-1613-9587
Aerts, Hugo J. W. L. http://orcid.org/0000-0002-2122-2003
,
Watkins, Thomas B. K.
Birkbak, Nicolai J.
Aerts, Hugo Jwl
Lester, Jason F.
Bajaj, Amrita
Nakas, Apostolos
Sodha-Ramdeen, Azmina
Ang, Keng
Tufail, Mohamad
Chowdhry, Mohammed Fiyaz
Scotland, Molly
Boyles, Rebecca
Rathinam, Sridhar
Wilson, Claire
Marrone, Domenic
Dulloo, Sean
Fennell, Dean A.
Matharu, Gurdeep
Shaw, Jacqui A.
Riley, Joan
Primrose, Lindsay
Boleti, Ekaterini
Cheyne, Heather
Khalil, Mohammed
Richardson, Shirley
Cruickshank, Tracey
Price, Gillian
Kerr, Keith M.
Benafif, Sarah
Gilbert, Kayleigh
Naidu, Babu
Patel, Akshay J.
Osman, Aya
Lacson, Christer
Langman, Gerald
Shackleford, Helen
Djearaman, Madava
Kadiri, Salma
Middleton, Gary
Leek, Angela
Hodgkinson, Jack Davies
Totten, Nicola
Montero, Angeles
Smith, Elaine
Fontaine, Eustace
Granato, Felice
Doran, Helen
Novasio, Juliette
Rammohan, Kendadai
Joseph, Leena
Bishop, Paul
Shah, Rajesh
Moss, Stuart
Joshi, Vijay
Crosbie, Philip
Gomes, Fabio
Brown, Kate
Carter, Mathew
Chaturvedi, Anshuman
Priest, Lynsey
Oliveira, Pedro
Lindsay, Colin R.
Blackhall, Fiona H.
Krebs, Matthew G.
Summers, Yvonne
Clipson, Alexandra
Tugwood, Jonathan
Kerr, Alastair
Rothwell, Dominic G.
Kilgour, Elaine
Dive, Caroline
Schwarz, Roland F.
Kaufmann, Tom L.
Wilson, Gareth A.
Rosenthal, Rachel
Van Loo, Peter
Szallasi, Zoltan
Kisistok, Judit
Sokac, Mateo
Diossy, Miklos
Demeulemeester, Jonas
Bunkum, Abigail
Stewart, Aengus
Magness, Alastair
Rowan, Andrew
Karamani, Angeliki
Chain, Benny
Campbell, Brittany B.
Castignani, Carla
Bailey, Chris
Abbosh, Christopher
Weeden, Clare E.
Lee, Claudia
Richard, Corentin
Hiley, Crispin T.
Moore, David A.
Pearce, David R.
Karagianni, Despoina
Biswas, Dhruva
Levi, Dina
Hoxha, Elena
Cadieux, Elizabeth Larose
Lim, Emilia L.
Colliver, Emma
Nye, Emma
Grönroos, Eva
Gálvez-Cancino, Felip
Athanasopoulou, Foteini
Gimeno-Valiente, Francisco
Kassiotis, George
Stavrou, Georgia
Mastrokalos, Gerasimos
Zhai, Haoran
Lowe, Helen L.
Matos, Ignacio Garcia
Goldman, Jacki
Reading, James L.
Herrero, Javier
Rane, Jayant K.
Nicod, Jerome
Hartley, John A.
Peggs, Karl S.
Enfield, Katey S. S.
Selvaraju, Kayalvizhi
Thol, Kerstin
Litchfield, Kevin
Ng, Kevin W.
Chen, Kezhong
Dijkstra, Krijn
Grigoriadis, Kristiana
Thakkar, Krupa
Ensell, Leah
Shah, Mansi
Duran, Marcos Vasquez
Litovchenko, Maria
Sunderland, Mariana Werner
Hill, Mark S.
Dietzen, Michelle
Leung, Michelle
Escudero, Mickael
Angelova, Mihaela
Tanić, Miljana
Sivakumar, Monica
Kanu, Nnennaya
Chervova, Olga
Lucas, Olivia
Pich, Oriol
Hobson, Philip
Pawlik, Piotr
Stone, Richard Kevin
Bentham, Robert
Hynds, Robert E.
Vendramin, Roberto
Saghafinia, Sadegh
López, Saioa
Gamble, Samuel
Ung, Seng Kuong Anakin
Quezada, Sergio A.
Vanloo, Sharon
Zaccaria, Simone
Hessey, Sonya
Boeing, Stefan
Beck, Stephan
Bola, Supreet Kaur
Denner, Tamara
Marafioti, Teresa
Mourikis, Thanos P.
Spanswick, Victoria
Barbè, Vittorio
Lu, Wei-Ting
Hill, William
Liu, Wing Kin
Wu, Yin
Naito, Yutaka
Ramsden, Zoe
Veiga, Catarina
Royle, Gary
Collins-Fekete, Charles-Antoine
Fraioli, Francesco
Ashford, Paul
Clark, Tristan
Forster, Martin D.
Lee, Siow Ming
Borg, Elaine
Falzon, Mary
Papadatos-Pastos, Dionysis
Wilson, James
Ahmad, Tanya
Procter, Alexander James
Ahmed, Asia
Taylor, Magali N.
Nair, Arjun
Lawrence, David
Patrini, Davide
Navani, Neal
Thakrar, Ricky M.
Janes, Sam M.
Hoogenboom, Emilie Martinoni
Monk, Fleur
Holding, James W.
Choudhary, Junaid
Bhakhri, Kunal
Scarci, Marco
Hayward, Martin
Panagiotopoulos, Nikolaos
Gorman, Pat
Khiroya, Reena
Stephens, Robert CM.
Wong, Yien Ning Sophia
Bandula, Steve
Sharp, Abigail
Smith, Sean
Gower, Nicole
Dhanda, Harjot Kaur
Chan, Kitty
Pilotti, Camilla
Leslie, Rachel
Grapa, Anca
Zhang, Hanyun
AbdulJabbar, Khalid
Pan, Xiaoxi
Yuan, Yinyin
Chuter, David
MacKenzie, Mairead
Chee, Serena
Alzetani, Aiman
Cave, Judith
Scarlett, Lydia
Richards, Jennifer
Ingram, Papawadee
Austin, Silvia
Lim, Eric
De Sousa, Paulo
Jordan, Simon
Rice, Alexandra
Raubenheimer, Hilgardt
Bhayani, Harshil
Ambrose, Lyn
Devaraj, Anand
Chavan, Hema
Begum, Sofina
Buderi, Silviu I.
Kaniu, Daniel
Malima, Mpho
Booth, Sarah
Nicholson, Andrew G.
Fernandes, Nadia
Shah, Pratibha
Proli, Chiara
Hewish, Madeleine
Danson, Sarah
Shackcloth, Michael J.
Robinson, Lily
Russell, Peter
Blyth, Kevin G.
Dick, Craig
Le Quesne, John
Kirk, Alan
Asif, Mo
Bilancia, Rocco
Kostoulas, Nikos
Thomas, Mathew
Jamal-Hanjani, Mariam http://orcid.org/0000-0003-1212-1259
Swanton, Charles http://orcid.org/0000-0002-4299-3018
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Funding
Funding for this research was provided by:
Deutsche Forschungsgemeinschaft (467697427)
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Article History
Received: 20 April 2022
Accepted: 24 January 2023
First Online: 12 April 2023
Competing interests
: O.A.S.: Advisory Board (AstraZeneca, AbbVie, Ascentage, Gilead, Janssen and Roche), speaker honoraria (Adaptive, AstraZeneca, AbbVie, BeiGene, Eli Lilly, Gilead, Janssen and Roche), research funding (BeiGene, AbbVie, Janssen and Roche). J.M.L. receives research funding from the NIHR. A.M.F. is a named inventor on a patent application to determine methods and systems for tumor monitoring (PCT/EP2022/077987). M.A.B. has consulted for Achilles Therapeutics. S.C.: employment (Pfizer). M.R. receives research funding from the NIH, Lustgarten Foundation, Stand Up to Cancer Foundation and the Hale Family Center for Pancreatic Cancer at DFCI. N.S.: consultancy and/or speaker honoraria for Abbott Laboratories, Afimmune, Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Hanmi Pharmaceuticals, Janssen, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer, Roche Diagnostics and Sanofi; research grants for AstraZeneca, Boehringer Ingelheim, Roche Diagnostics and Novartis. P.W.: grant income from Roche Diagnostics, AstraZeneca, Boehringer Ingelheim and Novartis and speaker’s fees from Novo Nordisk outside the submitted work. K.P. and M.F.B. actively direct Voronoi Health Analytics Incorporated, a Canadian corporation that sells commercial licenses for the DAFS software. R.H.M.: Advisory Board (ViewRay, AstraZeneca), consulting (Varian Medical Systems, Sio Capital Management), honorarium (Novartis, Springer Nature), ownership (Health-AI) and research funding (ViewRay). N.M. has stock options in and has consulted for Achilles Therapeutics and holds a European patents relating to targeting neoantigens (PCT/EP2016/ 059401), identifying patient response to immune checkpoint blockade (PCT/ EP2016/071471), determining HLA LOH (PCT/GB2018/052004), predicting survival rates of patients with cancer (PCT/GB2020/050221). D.M.B.: employment (Pfizer). S.O.R.: consultancy (Pfizer, AstraZeneca, Northsea and Third Rock Ventures). N.J.B. is a co-inventor of a patent to identify responders to cancer treatment (PCT/GB2018/051912), and a patent to predict HRD deficiency (US10190160B2). H.J.W.J.A. is scientific advisor and shareholder of Onc.AI, Love Health, Health-AI and Sphera, and receives consulting fees from BMS and Editas Medicine (all outside the presented work). M.J.-H. is a CRUK Career Establishment Awardee and has received funding from CRUK, IASLC International Lung Cancer Foundation, Lung Cancer Research Foundation, Rosetrees Trust, UKI NETs, NIHR and NIHR UCLH Biomedical Research Centre. M.J.-H. has consulted and is a member of the Scientific Advisory Board and Steering Committee, for Achilles Therapeutics, has received speaker honoraria from Astex Pharmaceuticals, Oslo Cancer Cluster and Pfizer, and is co-inventor on a patent PCT/US2017/028013 relating to methods for lung cancer detection. C.S. acknowledges grant support from AstraZeneca, Boehringer-Ingelheim, Bristol Myers Squibb, Pfizer, Roche-Ventana, Invitae (previously Archer Dx Inc - collaboration in minimal residual disease sequencing technologies), and Ono Pharmaceutical. C.S. is an AstraZeneca Advisory Board member and Chief Investigator for the AZ MeRmaiD 1 and 2 clinical trials and is also Co-Chief Investigator of the NHS Galleri trial funded by GRAIL and a paid member of GRAIL’s Scientific Advisory Board. He receives consultant fees from Achilles Therapeutics (also SAB member), Bicycle Therapeutics (also a SAB member), Genentech, Medicxi, Roche Innovation Centre – Shanghai, Metabomed (until July 2022), and the Sarah Cannon Research Institute. C.S. had stock options in Apogen Biotechnologies and GRAIL until June 2021, and currently has stock options in Epic Bioscience, Bicycle Therapeutics, and has stock options and is co-founder of Achilles Therapeutics. C.S. is an inventor on a European patent application relating to assay technology to detect tumour recurrence (PCT/GB2017/053289), the patent has been licensed to commercial entities and under his terms of employment with C.S due a revenue share of any revenue generated from such license(s). C.S. holds patents relating to targeting neoantigens (PCT/EP2016/059401), identifying patient response to immune checkpoint blockade (PCT/EP2016/071471), determining HLA LOH (PCT/GB2018/052004), predicting survival rates of patients with cancer (PCT/GB2020/050221), identifying patients who respond to cancer treatment (PCT/GB2018/051912), US patent relating to detecting tumour mutations (PCT/US2017/28013), methods for lung cancer detection (US20190106751A1) and both a European and US patent related to identifying insertion/deletion mutation targets (PCT/GB2018/051892) and is co-inventor to a patent application to determine methods and systems for tumour monitoring (PCT/EP2022/077987). C.S. is a named inventor on a provisional patent protection related to a ctDNA detection algorithm.
