Gonzales, Mitzi M.
Garbarino, Valentina R. http://orcid.org/0000-0002-0973-7186
Kautz, Tiffany F.
Palavicini, Juan Pablo http://orcid.org/0000-0001-9667-8438
Lopez-Cruzan, Marisa http://orcid.org/0000-0003-0285-1012
Dehkordi, Shiva Kazempour http://orcid.org/0000-0003-0349-4360
Mathews, Julia J.
Zare, Habil http://orcid.org/0000-0001-5902-6238
Xu, Peng http://orcid.org/0000-0001-8007-9879
Zhang, Bin
Franklin, Crystal
Habes, Mohamad
Craft, Suzanne
Petersen, Ronald C. http://orcid.org/0000-0002-8178-6601
Tchkonia, Tamara http://orcid.org/0000-0003-4623-7145
Kirkland, James L. http://orcid.org/0000-0003-1676-4905
Salardini, Arash
Seshadri, Sudha
Musi, Nicolas
Orr, Miranda E. http://orcid.org/0000-0002-0418-2724
Funding for this research was provided by:
Alzheimer’s Drug Discovery Foundation (GC-201908-2019443)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U24AG059624, R01AG068293, P30AG044271, R01AG077472, P30AG066546, T32AG021890, P30AG044271, PG30AG044271, P30AG013319, U01AG22307, R01AG068293, R01AG057896, 1RF1AG063507, 1R01AG0665241A, 1R01AG065301, P30 AG066546, U01AG046170, R01AG068030, R01AG080821, P30AG072947, P30 AG062677, U01 AG006786, U24 AG057437, U19 AG024904, R33AG061456, R37AG13925, P01AG062413, R01AG066524, R01AG054076, R01AG033193, RF1AG059421, P30AG066546, P30AG044271, P30AG013319, U54AG07594, R01AG069690, R01AG075684)
American Federation for Aging Research
U.S. Department of Veterans Affairs (I01BX005717)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R21NS125171, RF1NS112391, U19NS115388, UF1 NS125417, R01NS017950)
Hevolution Foundation
Institute for Integration of Medicine & Science and the Center for Biomedical Neurosciences at UT Health Science Center in San Antonio
U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (TR002647)
Institute for Integration of Medicine & Science at UT Health Science Center in San Antonio. Center for Biomedical Neurosciences at UT Health Science Center in San Antonio.
Cure Alzheimer’s Fund
GHR Foundation
Alzheimer’s Association (PTC REG-20-651687)
Connor Fund Robert J. and Theresa W. Ryan Noaber Foundation
National Heart and Lung Institute (R01HL105756)
JMR Barker Foundation; Bill and Rebecca Reed Endowments for Precision Medicine and Palliative Care; Kleberg/McGill Foundation; UT STARS
Article History
Received: 12 April 2023
Accepted: 14 August 2023
First Online: 7 September 2023
Change Date: 14 December 2023
Change Type: Update
Change Details: In the version of the article initially published, part of Extended Data Table 3 was missing but has now been added.
Competing interests
: M.M.G. reports personal stock in Abbvie. R.C.P. reports personal fees from Roche, no personal fees from Eisai, and personal fees from Genentech, personal fees from Eli Lilly and personal fees from Nestle, outside the submitted work. R.C.P. receives royalties from Oxford University Press and UpToDate and receives fees from Medscape for educational activities. J.L.K. and T.T. have a patent for Killing Senescent Cells and Treating Senescence-Associated Conditions Using an SRC Inhibitor and a Flavonoid with royalties paid to Mayo Clinic by Unity Biotechnologies and a patent for Treating Cognitive Decline and Other Neurodegenerative Conditions by Selectively Removing Senescent Cells from Neurological Tissue with royalties paid to Mayo Clinic by Unity Biotechnologies. S.C. reports Scientific Advisory Board membership for T3D Therapeutics and the Neurodegenerative Consortium, outside the submitted work. M.E.O., H.Z. and S.K.D. have a patent for Biosignature and therapeutic approach for neuronal senescence, which is pending. The remaining authors declare no competing interests.