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,
Funding for this research was provided by:
Johnson and Johnson
Article History
Received: 24 April 2025
Accepted: 16 June 2025
First Online: 15 July 2025
Competing interests
: A.L.B. receives research support from the NIH, the Tau Research Consortium, the Association for Frontotemporal Degeneration, Bluefield Project to Cure Frontotemporal Dementia, the GHR Foundation and the Alzheimer’s Association. He has been a consultant for Alchemab, Alector, Alexion, Amylyx, Arrowhead, Arvinas, Eli Lilly, Muna, Neurocrine, Ono, Oscotec, Pfizer, Switch, Transposon and UnlearnAI. C.C. has received research support from GSK and Eisai. C.C. is a member of the scientific advisory board of Circular Genomics and owns stocks. C.C. is a member of the scientific advisory board of ADmit. J.L.D. has a patent pending for compounds and methods targeting human tau. L.F. has given unpaid seminars and/or webinars sponsored or co-sponsored by SomaLogic. O.H. has received nonfinancial support from Roache and Lilly and is currently employed by Lilly. E.M.R. has received grants from National Institute on Aging and the state of Arizona; receives philanthropic funding from the Banner Alzheimer’s Foundation, Sun Health Foundation and Roche/Roche Diagnostics; receives personal fees from Alkahest, Alzheon, Aural Analytics, Denali, Green Valley, MagQ, Takeda/Zinfandel and United Neuroscience; has since submission of manuscript become a cofounder of ALZpath, which aims to further develop P-tau217 and fluid biomarkers and advance their use in research, drug development and clinical settings; holds a patent owned by Banner Health for a strategy to use biomarkers to accelerate evaluation of Alzheimer prevention therapies; and is a principal investigator of prevention trials that include research agreements with Genentech/Roche and Novartis/Amgen, PET studies that include research agreements with Avid/Lilly and several NIH and Foundation-supported research studies. T.W.-C. and H.S.-H.O. are co-founders and scientific advisors of Teal Omics Inc. and have received equity stakes. T.W.-C. is a co-founder and scientific advisor of Alkahest Inc. and Qinotto Inc. and has received equity stakes in these companies. The other authors declare no competing interests.