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Cui, Hejie
Fuentes, Miguel https://orcid.org/0009-0002-1930-9529
Unell, Alyssa
Wornow, Michael
Banda, Juan M. https://orcid.org/0000-0001-8499-824X
Kotecha, Nikesh
Keyes, Timothy https://orcid.org/0000-0003-0423-9679
Mai, Yifan https://orcid.org/0009-0004-7270-2607
Oez, Mert
Qiu, Hao
Jain, Shrey
Schettini, Leonardo https://orcid.org/0009-0005-8373-7140
Kashyap, Mehr
Fries, Jason Alan https://orcid.org/0000-0001-9316-5768
Swaminathan, Akshay
Chung, Philip https://orcid.org/0000-0002-1194-7510
Haredasht, Fateme Nateghi https://orcid.org/0000-0002-8874-8835
Lopez, Ivan https://orcid.org/0000-0003-0246-2180
Aali, Asad https://orcid.org/0009-0008-2120-5722
Tse, Gabriel
Nayak, Ashwin
Vedak, Shivam https://orcid.org/0009-0009-5034-0699
Jain, Sneha S. https://orcid.org/0000-0002-0592-1453
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Fayanju, Oluseyi
Shah, Shreya
Goh, Ethan https://orcid.org/0009-0001-7491-4257
Yao, Dong-han
Soetikno, Brian
Reis, Eduardo
Gatidis, Sergios
Divi, Vasu
Capasso, Robson https://orcid.org/0000-0003-2645-1793
Saralkar, Rachna
Chiang, Chia-Chun https://orcid.org/0000-0001-7802-7172
Jindal, Jenelle https://orcid.org/0000-0002-3959-5748
Pham, Tho
Ghoddusi, Faraz https://orcid.org/0009-0005-1487-3237
Lin, Steven
Chiou, Albert S. https://orcid.org/0000-0002-8436-0008
Hong, Hyo Jung
Roy, Mohana
Gensheimer, Michael F. https://orcid.org/0000-0002-4897-3843
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Schulman, Kevin https://orcid.org/0000-0002-8926-5085
Dash, Dev
Char, Danton
Downing, Lance
Grolleau, Francois
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Mieso, Bethel
Zahedivash, Aydin
Yim, Wen-wai
Sharma, Harshita https://orcid.org/0000-0003-4683-2606
Lee, Tony
Kirsch, Hannah
Lee, Jennifer
Ambers, Nerissa https://orcid.org/0009-0008-9878-1824
Lugtu, Carlene
Sharma, Aditya https://orcid.org/0009-0002-5351-9271
Mawji, Bilal
Alekseyev, Alex
Zhou, Vicky
Kakkar, Vikas
Helzer, Jarrod
Revri, Anurang
Bannett, Yair https://orcid.org/0000-0001-5134-3300
Daneshjou, Roxana https://orcid.org/0000-0001-7988-9356
Chen, Jonathan https://orcid.org/0000-0002-4387-8740
Alsentzer, Emily
Morse, Keith
Ravi, Nirmal https://orcid.org/0000-0002-5146-2569
Aghaeepour, Nima https://orcid.org/0000-0002-6117-8764
Kennedy, Vanessa
Chaudhari, Akshay https://orcid.org/0000-0002-3667-6796
Wang, Thomas https://orcid.org/0009-0000-1686-4178
Koyejo, Sanmi https://orcid.org/0000-0002-4023-419X
Lungren, Matthew P.
Horvitz, Eric https://orcid.org/0000-0002-8823-0614
Liang, Percy
Pfeffer, Michael A. https://orcid.org/0000-0002-8958-0843
Shah, Nigam H. https://orcid.org/0000-0001-9385-7158
Article History
Received: 3 June 2025
Accepted: 24 November 2025
First Online: 20 January 2026
Competing interests
: M.O., H.Q., S.J. and L.S. are employees of Microsoft. J.A.F. reports healthcare AI consulting for Snorkel AI and holds stock options in Snorkel AI. This entity had no role in study design, data collection or analysis, decision to publish, or manuscript preparation. A.S. reports employment and owning stock options in Benchmark Health and Daybreak Health; work is unrelated to the research topics explored in MedHELM. P.C. is a Healthcare AI Data Specialist consultant working with OpenAI; this work is unrelated to the research topics explored in MedHELM. A.N. reports cofounding and owning stock in UpDoc. This entity was not involved in any way with the work presented. S.V. reports previously working as an independent contractor for OpenAI’s health and safety initiatives; this work was unrelated to the research topics explored in MedHELM. J.J. is the founder of Jindal Neurology and a per diem physician with Kaiser Permanente. D.Y. reports previously working as an independent contractor for OpenAI’s health and safety initiatives; this work was unrelated to the research topics explored in MedHELM. R.C. reports research funding from Samsung Electronics and serving as advisor to XP Health. None of these entities were involved in any way with the work presented. F.G. is Executive Director of Healthy Oregon and Chief Medical Information Officer at Empathia.ai; none of these entities were involved in any way with the work presented. S.L. serves as an advisor to Google, Codex Health, Gaia Health and Added Health. None of these entities were involved in any way with the work presented. M.F.G. reports institutional grant funding from Xrad Therapeutics. K.S. is a shareholder and advisor to UpDoc, Salud Now, Medeloop and Alethia. None of these entities were involved in any way with the work presented. J.H.C. has received research funding support from: NIH/National Institute of Allergy and Infectious Diseases (1R01AI17812101); NIH-NCATS Clinical and Translational Science Award (UM1TR004921); Stanford Bio-X Interdisciplinary Initiatives Seed Grants Program (IIP); NIH/Center for Undiagnosed Diseases at Stanford (U01 NS134358); Stanford RAISE Health Seed Grant 2024; and Josiah Macy Jr. Foundation (AI in Medical Education). J.H.C. is also cofounder of Reaction Explorer, which develops and licenses organic chemistry education software, and has received paid medical expert witness fees (Sutton Pierce, Younker Hyde MacFarlane, Sykes McAllister, Elite Experts), consulting fees from ISHI Health, and one-time honoraria or travel expenses for invited presentations from insitro, General Reinsurance Corporation, AASCIF, Cozeva and other industry conferences, academic institutions and health systems. E.A. reports consulting fees and stock from Fourier Health. N.A. reports serving on Scientific Advisory Boards for January AI, Parallel Bio and Medeloop, and cofounding Takeoff41. None of these entities were involved in any way with the work presented. A.C. reports cofounding and owning stock in Cognita Imaging; owning stock in Subtle Medical, BrainKey and LVIS Corp; and providing consulting services to Elucid Bioimaging and Patient Square Capital. None of these entities were involved in any way with the work presented. S.K. reports cofounding and owning stock options in Virtue AI; this work is unrelated to the research topics explored in MedHELM. E.H. reports serving in a senior role at Microsoft and owning stock in Microsoft, which has efforts in the healthcare domain. M.A.P. is an advisor to Akasa and Surgical Safety Technologies. None of these entities were involved in any way with the work presented. N.H.S. reports being a cofounder of Prealize Health and Atropos Health, serving on the Board of the Coalition for Healthcare AI, and serving as an advisor to Opala, Curai Health, JnJ Innovative Medicines and AbbVie pharmaceuticals. None of these entities were involved in any way with the work presented. The other authors declare no competing interests.