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Integration of imaging-based and sequencing-based spatial omics mapping on the same tissue section via DBiTplus

Crossref DOI link: https://doi.org/10.1038/s41592-025-02948-0

Published Online: 2026-01-15

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Enninful, Archibald

Zhang, Zhaojun

Klymyshyn, Dmytro

Ingalls, Matthew https://orcid.org/0000-0001-6430-9785
Yang, Mingyu https://orcid.org/0000-0003-0986-3825
Zong, Hailing

Bai, Zhiliang https://orcid.org/0000-0002-3977-3057
Farzad, Negin

Su, Graham

Baysoy, Alev

Nam, Jungmin https://orcid.org/0000-0002-6717-1328
Lu, Yao

Bao, Shuozhen

Deng, Siyan

Zhang, Nancy R. https://orcid.org/0000-0002-0880-5749
Braubach, Oliver

Xu, Mina L. https://orcid.org/0000-0001-9513-245X
Ma, Zongming https://orcid.org/0000-0003-2401-0177
Fan, Rong https://orcid.org/0000-0001-7805-8059
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Cancer Institute (U54CA274509)

U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA245313)

U.S. Department of Health & Human Services | NIH | National Cancer Institute (U54CA268083)

U.S. Department of Health & Human Services | National Institutes of Health (UH3CA257393)

U.S. Department of Health & Human Services | National Institutes of Health (RF1MH128876)

U.S. Department of Health & Human Services | National Institutes of Health (U54AG079759)

U.S. Department of Health & Human Services | National Institutes of Health (U54AG076043)

U.S. Department of Health & Human Services | National Institutes of Health (RM1MH132648)

U.S. Department of Health & Human Services | National Institutes of Health (U01CA294514)

Center for Selective C-H Functionalization, National Science Foundation (2245575)

Center for Selective C-H Functionalization, National Science Foundation (2245575)

National Science Foundation (2345215)

National Science Foundation (2245575)
License Information

Text and Data Mining valid from 2026-01-15

Version of Record valid from 2026-01-15
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Article History

Received: 5 November 2024

Accepted: 27 October 2025

First Online: 15 January 2026

Competing interests

: R.F. is scientific founder and adviser for IsoPlexis, Singleron Biotechnologies and AtlasXomics. The interests of R.F. were reviewed and managed by Yale University Provost’s Office in accordance with the University’s conflict of interest policies. M.L.X. has served as consultant for Treeline Biosciences, Pure Marrow and Seattle Genetics. The other authors declare no competing interests.

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