Crossmark

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Crossref DOI link: https://doi.org/10.1038/s41593-022-01042-4

Published Online: 2022-04-05

Published Print: 2022-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Brouwer, Rachel M. https://orcid.org/0000-0002-7466-1544
Klein, Marieke

Grasby, Katrina L. https://orcid.org/0000-0001-8539-0228
Schnack, Hugo G. https://orcid.org/0000-0002-4620-3853
Jahanshad, Neda https://orcid.org/0000-0003-4401-8950
Teeuw, Jalmar

Thomopoulos, Sophia I.

Sprooten, Emma https://orcid.org/0000-0002-1691-9105
Franz, Carol E.

Gogtay, Nitin

Kremen, William S. https://orcid.org/0000-0002-8629-5609
Panizzon, Matthew S.

Olde Loohuis, Loes M. https://orcid.org/0000-0002-3327-7837
Whelan, Christopher D.

Aghajani, Moji

Alloza, Clara

Alnæs, Dag https://orcid.org/0000-0001-7361-5418
Artiges, Eric https://orcid.org/0000-0003-4461-7646
Ayesa-Arriola, Rosa

Barker, Gareth J. https://orcid.org/0000-0002-5214-7421
Bastin, Mark E.

Blok, Elisabet

Bøen, Erlend https://orcid.org/0000-0002-9546-2763
Breukelaar, Isabella A. https://orcid.org/0000-0002-6241-5274
Bright, Joanna K.

Buimer, Elizabeth E. L. https://orcid.org/0000-0002-8143-3160
Bülow, Robin https://orcid.org/0000-0003-1884-5784
Cannon, Dara M. https://orcid.org/0000-0001-7378-3411
Ciufolini, Simone

Crossley, Nicolas A.

Damatac, Christienne G. https://orcid.org/0000-0001-9495-5243
Dazzan, Paola https://orcid.org/0000-0002-8427-3617
de Mol, Casper L.

de Zwarte, Sonja M. C.

Desrivières, Sylvane https://orcid.org/0000-0002-9120-7060
Díaz-Caneja, Covadonga M. https://orcid.org/0000-0001-8538-3175
Doan, Nhat Trung

Dohm, Katharina

Fröhner, Juliane H. https://orcid.org/0000-0002-8493-6396
Goltermann, Janik https://orcid.org/0000-0003-3087-1002
Grigis, Antoine

Grotegerd, Dominik

Han, Laura K. M. https://orcid.org/0000-0001-9647-3723
Harris, Mathew A. https://orcid.org/0000-0002-1135-4141
Hartman, Catharina A.

Heany, Sarah J.

Heindel, Walter

Heslenfeld, Dirk J.

Hohmann, Sarah

Ittermann, Bernd

Jansen, Philip R. https://orcid.org/0000-0003-1550-2444
Janssen, Joost

Jia, Tianye https://orcid.org/0000-0001-5399-2953
Jiang, Jiyang https://orcid.org/0000-0002-2147-6302
Jockwitz, Christiane

Karali, Temmuz

Keeser, Daniel https://orcid.org/0000-0002-0244-1024
Koevoets, Martijn G. J. C. https://orcid.org/0000-0002-8347-0379
Lenroot, Rhoshel K.

Malchow, Berend

Mandl, René C. W.

Medel, Vicente https://orcid.org/0000-0003-2443-8683
Meinert, Susanne

Morgan, Catherine A. https://orcid.org/0000-0002-5837-8861
Mühleisen, Thomas W. https://orcid.org/0000-0002-6057-5952
Nabulsi, Leila https://orcid.org/0000-0001-9448-7769
Opel, Nils

de la Foz, Víctor Ortiz-García

Overs, Bronwyn J. https://orcid.org/0000-0002-7138-5556
Paillère Martinot, Marie-Laure

Redlich, Ronny

Marques, Tiago Reis https://orcid.org/0000-0003-0602-7661
Repple, Jonathan

Roberts, Gloria

Roshchupkin, Gennady V. https://orcid.org/0000-0002-3403-2313
Setiaman, Nikita https://orcid.org/0000-0001-9951-0665
Shumskaya, Elena

Stein, Frederike

Sudre, Gustavo

Takahashi, Shun

Thalamuthu, Anbupalam

Tordesillas-Gutiérrez, Diana https://orcid.org/0000-0003-1458-3932
van der Lugt, Aad

van Haren, Neeltje E. M.

Wardlaw, Joanna M. https://orcid.org/0000-0002-9812-6642
Wen, Wei https://orcid.org/0000-0003-2753-3870
Westeneng, Henk-Jan

Wittfeld, Katharina https://orcid.org/0000-0003-4383-5043
Zhu, Alyssa H.

Zugman, Andre

Armstrong, Nicola J.

Bonfiglio, Gaia

Bralten, Janita

Dalvie, Shareefa https://orcid.org/0000-0003-2333-4823
Davies, Gail https://orcid.org/0000-0003-1120-7026
Di Forti, Marta

Ding, Linda

Donohoe, Gary https://orcid.org/0000-0003-3037-7426
Forstner, Andreas J.

Gonzalez-Peñas, Javier

Guimaraes, Joao P. O. F. T.

Homuth, Georg

Hottenga, Jouke-Jan https://orcid.org/0000-0002-5668-2368
Knol, Maria J. https://orcid.org/0000-0002-3597-1531
Kwok, John B. J.

Le Hellard, Stephanie https://orcid.org/0000-0002-8085-051X
Mather, Karen A. https://orcid.org/0000-0003-4143-8941
Milaneschi, Yuri https://orcid.org/0000-0002-3697-6617
Morris, Derek W. https://orcid.org/0000-0002-3413-570X
Nöthen, Markus M. https://orcid.org/0000-0002-8770-2464
Papiol, Sergi https://orcid.org/0000-0001-9366-8728
Rietschel, Marcella https://orcid.org/0000-0002-5236-6149
Santoro, Marcos L. https://orcid.org/0000-0001-5714-9509
Steen, Vidar M.

Stein, Jason L. https://orcid.org/0000-0003-4829-0513
Streit, Fabian https://orcid.org/0000-0003-1080-4339
Tankard, Rick M.

Teumer, Alexander https://orcid.org/0000-0002-8309-094X
van ‘t Ent, Dennis https://orcid.org/0000-0003-2001-1375
van der Meer, Dennis https://orcid.org/0000-0002-0466-386X
van Eijk, Kristel R.

Vassos, Evangelos https://orcid.org/0000-0001-6363-0438
Vázquez-Bourgon, Javier https://orcid.org/0000-0002-5478-3376
Witt, Stephanie H. https://orcid.org/0000-0002-1571-1468
,

Brühl, Rüdiger

Papadopoulos Orfanos, Dimitri

Paus, Tomáš

Millenet, Sabina

Adams, Hieab H. H. https://orcid.org/0000-0003-3687-2508
Agartz, Ingrid

Ames, David

Amunts, Katrin https://orcid.org/0000-0001-5828-0867
Andreassen, Ole A. https://orcid.org/0000-0002-4461-3568
Arango, Celso https://orcid.org/0000-0003-3382-4754
Banaschewski, Tobias https://orcid.org/0000-0003-4595-1144
Baune, Bernhard T.

Belangero, Sintia I. https://orcid.org/0000-0002-2419-4351
Bokde, Arun L. W. https://orcid.org/0000-0003-0114-4914
Boomsma, Dorret I. https://orcid.org/0000-0002-7099-7972
Bressan, Rodrigo A.

Brodaty, Henry https://orcid.org/0000-0001-9487-6617
Buitelaar, Jan K. https://orcid.org/0000-0001-8288-7757
Cahn, Wiepke

Caspers, Svenja

Cichon, Sven https://orcid.org/0000-0002-9475-086X
Crespo-Facorro, Benedicto

Cox, Simon R. https://orcid.org/0000-0003-4036-3642
Dannlowski, Udo https://orcid.org/0000-0002-0623-3759
Elvsåshagen, Torbjørn https://orcid.org/0000-0001-9991-1610
Espeseth, Thomas

Falkai, Peter G.

Fisher, Simon E. https://orcid.org/0000-0002-3132-1996
Flor, Herta

Fullerton, Janice M. https://orcid.org/0000-0003-4014-4490
Garavan, Hugh https://orcid.org/0000-0002-8939-1014
Gowland, Penny A. https://orcid.org/0000-0002-4900-4817
Grabe, Hans J. https://orcid.org/0000-0003-3684-4208
Hahn, Tim https://orcid.org/0000-0001-6541-3795
Heinz, Andreas https://orcid.org/0000-0001-5405-9065
Hillegers, Manon https://orcid.org/0000-0003-4877-282X
Hoare, Jacqueline https://orcid.org/0000-0002-6963-3557
Hoekstra, Pieter J.

Ikram, Mohammad A. https://orcid.org/0000-0003-0372-8585
Jackowski, Andrea P. https://orcid.org/0000-0001-8842-5406
Jansen, Andreas

Jönsson, Erik G.

Kahn, Rene S. https://orcid.org/0000-0001-5909-8004
Kircher, Tilo

Korgaonkar, Mayuresh S. https://orcid.org/0000-0002-1339-2221
Krug, Axel https://orcid.org/0000-0002-0564-2497
Lemaitre, Herve

Malt, Ulrik F. https://orcid.org/0000-0002-9881-2511
Martinot, Jean-Luc https://orcid.org/0000-0002-0136-0388
McDonald, Colm https://orcid.org/0000-0003-1661-5192
Mitchell, Philip B.

Muetzel, Ryan L. https://orcid.org/0000-0003-3215-1287
Murray, Robin M. https://orcid.org/0000-0003-0829-0519
Nees, Frauke https://orcid.org/0000-0002-7796-8234
Nenadić, Igor

Oosterlaan, Jaap https://orcid.org/0000-0002-0218-5630
Ophoff, Roel A. https://orcid.org/0000-0002-8287-6457
Pan, Pedro M.

Penninx, Brenda W. J. H.

Poustka, Luise

Sachdev, Perminder S. https://orcid.org/0000-0002-9595-3220
Salum, Giovanni A.

Schofield, Peter R. https://orcid.org/0000-0003-2967-9662
Schumann, Gunter https://orcid.org/0000-0002-7740-6469
Shaw, Philip https://orcid.org/0000-0002-1313-2526
Sim, Kang https://orcid.org/0000-0003-3209-9626
Smolka, Michael N. https://orcid.org/0000-0001-5398-5569
Stein, Dan J. https://orcid.org/0000-0001-7218-7810
Trollor, Julian N. https://orcid.org/0000-0002-7685-2977
van den Berg, Leonard H.

Veldink, Jan H. https://orcid.org/0000-0001-5572-9657
Walter, Henrik https://orcid.org/0000-0002-9403-6121
Westlye, Lars T. https://orcid.org/0000-0001-8644-956X
Whelan, Robert

White, Tonya

Wright, Margaret J. https://orcid.org/0000-0001-7133-4970
Medland, Sarah E. https://orcid.org/0000-0003-1382-380X
Franke, Barbara https://orcid.org/0000-0003-4375-6572
Thompson, Paul M.

Hulshoff Pol, Hilleke E. https://orcid.org/0000-0002-2038-5281
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R56AG058854, R56 AG058854, R01 AG058854, R01AG058854)

U.S. Department of Health & Human Services | National Institutes of Health (U54 EB020403)
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Text and Data Mining valid from 2022-04-01

Version of Record valid from 2022-04-01
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Article History

Received: 28 August 2020

Accepted: 28 February 2022

First Online: 5 April 2022

Competing interests

: B.F. has received speaking fees from MEDICE Arzneimittel Pütter GmbH & Co. B.W.J.H.P. has received research funding from Jansen Research and Boehringer Ingelheim. C.A. has been a consultant to or has received honoraria or grants from Acadia, Angelini, Gedeon Richter, Janssen Cilag, Lundbeck, Minerva, Otsuka, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda. C.D.W. is an employee of Biogen, Inc. D.J.S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. G.J.B. receives honoraria for teaching from GE Healthcare. H.B. is on the Advisory Board Nutricia Australia. H.E.H. has received travel fees for membership of the Steering Committee of the Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research and for two presentations from Philips. These concerned activities were unrelated to the submitted work. H.J.G. has received travel grants and speaker’s honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. L.P. has served as an advisor or consultant to Shire, Takeda and Roche. L.P. has also received speaking fees from Shire and Infectopharm. The present work is unrelated to these relationships. M.H.J. received grant support from the Brain and Behavior Foundation (NARSAD) Independent Investigator grant 20244. M.M.N. has received fees for memberships in Scientific Advisory Boards from the Lundbeck Foundation and Robert Bosch Stiftung and for membership in the Medical-Scientific Editorial Office of the Deutsches Ärzteblatt. M.M.N. was reimbursed travel expenses for a conference participation by Shire Deutschland GmbH. M.M.N. receives salary payments from Life & Brain GmbH and holds shares in Life & Brain GmbH. All these concerned activities are outside the submitted work. N.J. and P.M.T. are multiple principal investigators of a research grant from Biogen, Inc for work unrelated to the contents of this manuscript. O.A.A. has received speaker’s honoraria from Lundbeck and has been a consultant for HealthLytix. P.S.S. reports on/off payment for an advisory board meeting of Biogen. T.B. served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire and Infectopharm. T.B. also received conference support or speaker’s fees from Lilly, Medice and Shire and received royalties from Hogrefe, Kohlhammer, CIP Medien and Oxford University Press. The present work is unrelated to these relationships. T.E.l. has received speaker’s fees from Lundbeck. T.R.M. has received honoraria for speaking and chairing engagements from Lundbeck, Janssen and Astellas. Other authors declare no conflicts of interest.

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