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An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

Crossref DOI link: https://doi.org/10.1038/s41593-025-02022-0

Published Online: 2025-07-30

Published Print: 2025-09

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Thompson, Jacqueline R.

Nelson, Erik D.

Tippani, Madhavi https://orcid.org/0000-0002-6465-6418
Ramnauth, Anthony D.

Divecha, Heena R. https://orcid.org/0000-0002-1959-0675
Miller, Ryan A.

Eagles, Nicholas J. https://orcid.org/0000-0002-9808-5254
Pattie, Elizabeth A.

Kwon, Sang Ho

Bach, Svitlana V.

Kaipa, Uma M.

Yao, Jianing

Hou, Christine

Kleinman, Joel E. https://orcid.org/0000-0002-4210-6052
Collado-Torres, Leonardo

Han, Shizhong https://orcid.org/0000-0002-5114-6742
Maynard, Kristen R. https://orcid.org/0000-0003-0031-8468
Hyde, Thomas M. https://orcid.org/0000-0002-8746-3037
Martinowich, Keri https://orcid.org/0000-0002-5237-0789
Page, Stephanie C. https://orcid.org/0000-0002-1951-7398
Hicks, Stephanie C. https://orcid.org/0000-0002-7858-0231
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH122849)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH105592)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG083328)
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Text and Data Mining valid from 2025-07-30

Version of Record valid from 2025-07-30
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Article History

Received: 29 April 2024

Accepted: 16 June 2025

First Online: 30 July 2025

Competing interests

: E.D.N. is now a full-time employee at GSK, which is unrelated to the contents of this manuscript. His contributions to this manuscript were made while previously enrolled as a student at Johns Hopkins University and performing research at the Lieber Institute for Brain Development (LIBD). J.E.K. is a consultant on a Data Monitoring Committee for an antipsychotic drug trial for Merck & Co. The other authors declare no competing interests.

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