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Authors
Annunziato, Stefano
Quan, Chao https://orcid.org/0009-0007-0005-7305
Donckele, Etienne J.
Lamberto, Ilaria
Bunker, Richard D. https://orcid.org/0000-0001-8866-5290
Zlotosch, Mary
Schwander, Laura
Murthy, Anastasia
Wiedmer, Lars
Staehly, Camille
Matysik, Michelle https://orcid.org/0009-0000-9870-2382
Gilberto, Samuel https://orcid.org/0000-0002-6395-5897
Kapsitidou, Despina
Wible, Daric
De Donatis, Gian Marco
Trenh, Peter https://orcid.org/0000-0002-6135-2566
SriRamaratnam, Rohitha
Strande, Vaik
Lieberherr, Raphael https://orcid.org/0000-0003-0420-6981
Lyon, David
Steiner, Danielle
Silva, Joao
Almeida, Reinaldo
Dolgikh, Elena
DeMarco, Bradley
Tsai, Jennifer
Sadok, Amine https://orcid.org/0000-0003-0415-3664
Zarayskiy, Vladislav
Walter, Magnus
Tiedt, Ralph
Lumb, Kevin J. https://orcid.org/0000-0003-2778-9956
Bonenfant, Debora
Fasching, Bernhard
Castle, John C.
Townson, Sharon A. https://orcid.org/0000-0002-4933-4189
Gainza, Pablo https://orcid.org/0000-0001-9197-0982
Petzold, Georg https://orcid.org/0000-0001-5649-1716
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Article History
Received: 13 May 2025
Accepted: 12 December 2025
First Online: 20 January 2026
Competing interests
: All authors are current or former employees of Monte Rosa Therapeutics, an MGD company. Monte Rosa Therapeutics has filed the following patent applications: ‘Methods of designing MGDs’ (WO2024086347A1; E.D., P.G., L.W. and B.F.), ‘Degron and neosubstrate identification’ (WO2023091567A1; P.G., J.C.C., S.A.T. and R.D.B.), ‘Degron identification using neural networks’ (WO2023091584A1; P.G. and J.C.C.) and ‘Methods for the identification of degrons’ (US20240085421A1; R.D.B.).
