Guan, Kaoling https://orcid.org/0000-0001-6530-3705
Ocampo, Rodrigo Fregoso https://orcid.org/0009-0006-0951-8975
Matheus Carnevali, Paula B.
Castelle, Cindy J.
Gonzalez-Osorio, Liliana
Castanzo, Dominic T.
Thomas, Nicole C.
Brothers, Molly
Dangerfield, Tyler L. https://orcid.org/0000-0003-1413-2082
Hooper, Matthew M. https://orcid.org/0000-0002-4889-3288
West, Madeline S.
Appleby, Nathan M.
Krudop, Isabella
Lamothe, Rebecca C.
Aliaga Goltsman, Daniela S.
Alexander, Lisa M. https://orcid.org/0000-0003-0152-4554
Butterfield, Cristina N.
Johnson, Kenneth A.
Brown, Christopher T. https://orcid.org/0000-0002-7758-6447
Taylor, David W. https://orcid.org/0000-0002-6198-1194
Article History
Received: 18 June 2025
Accepted: 4 March 2026
First Online: 13 April 2026
Competing interests
: P.B.M.C., C.J.C., L.G.-O., L.M.A., D.T.C., M.B., R.C.L., N.C.T., D.S.A.G., C.N.B. and C.T.B. are or were employees of Metagenomi Therapeutics and inventors on pending patent applications. K.A.J. is the President of KinTek, which provided the AutoSF-120 stopped-flow instrument and the KinTek Explorer software used in this study. D.W.T. has a sponsored research agreement with Metagenomi. The other authors declare no competing interests.