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Authors
Nathans, Jenny F. https://orcid.org/0000-0002-0276-734X
McDiarmid, Troy A. https://orcid.org/0000-0002-4893-9733
Chen, Wei https://orcid.org/0000-0002-5255-4166
Shendure, Jay https://orcid.org/0000-0002-1516-1865
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Funding
Funding for this research was provided by:
Howard Hughes Medical Institute
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (R01HG010632)
Paul G. Allen Family Foundation
Brotman Baty Institute for Precision Medicine, Seattle Hub for Synthetic Biology
UW ISCRM Fellows Program
Banting Research Foundation
Damon Runyon Cancer Research Foundation (DRG-2507-23)
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Article History
Received: 23 June 2025
Accepted: 10 December 2025
First Online: 11 February 2026
Competing interests
: The University of Washington has filed a patent application partially based on this work, in which W.C. and J.S. are listed as inventors (patent application no. US-20240355418-A1, US region). J.S. is on the scientific advisory board, a consultant and/or a cofounder of Prime Medicine, Guardant Health, Camp4 Therapeutics, Phase Genomics, Adaptive Biotechnologies, Sixth Street Capital, Pacific Biosciences, Somite AI and 10x Genomics. J.N. and T.M. declare no competing interests.
