Updates are available Correction dated 2022-04-20

Article History

Received: 9 February 2021

Accepted: 12 May 2021

First Online: 26 May 2021

Change Date: 20 April 2022

Change Type: Correction

Change Details: A Correction to this paper has been published:

Change Details: https://doi.org/10.1038/s41598-022-10916-3

Competing interests

: There are no direct conflicts of interest with respect to this study. This study was not influenced by a third party. PA has participated in meetings sponsored by, received speaker honoraria or travel funding from Biogen, Merck, Roche, Sanofi-Genzyme and Teva, and received honoraria for consulting from Biogen. He received a research grant from Quanterix International and received funding for the development of a smartphone application for a clinical study from Biogen, Merck, Roche, Sanofi-Genzyme and Teva. MP has nothing to disclose. PSR has received honoraria for consultancy/speaking from AbbVie, Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sandoz, Sanofi-Genzyme, has received research grants from Amicus, Biogen, Merck and Roche. HH received an infrastructural grant from the Austrian Federal Ministry for Science, Research and Education (BBMRI.at) and compensations for Biobanking services in the framework of clinical trials from Glock Health and Blue-Skye Vaccines. PM has nothing to disclose. FL has participated in meetings sponsored by or received honoraria for acting as an advisor/speaker for Bayer, Biogen, Celgene, MedDay, Merck, Novartis, Roche, Sanofi-Genzyme and Teva. AP is a member of the steering committee for the OCTiMS study (Novartis) and ARI network (Zeiss), for which he did not receive any consulting fees. He performed quality control on optical coherence tomography for the Passos study (Novartis), for which he received consulting fees. He received speaker fees from Heidelberg Engineering. CW has nothing to disclose. RL received conference speaker honoraria within the last three years from Bruker BioSpin MR, and support from Siemens Healthcare regarding clinical research using PET/MR. He is a shareholder of the start-up company BM Health GmbH since 2019. TB has participated in meetings sponsored by and received honoraria (lectures, advisory boards, consultations) from pharmaceutical companies marketing treatments for MS: Allergan, Bayer, Biogen, Bionorica, Celgene, MedDay, Merck, Novartis, Octapharma, Roche, Sanofi-Genzyme, Teva. His institution has received financial support in the past 12 months by unrestricted research grants (Biogen, Bayer, Merck, Novartis, Sanofi Aventis, Teva and for participation in clinical trials in multiple sclerosis sponsored by Alexion, Bayer, Biogen, Merck, Novartis, Octapharma, Roche, Sanofi-Genzyme, Teva. HZ has served at scientific advisory boards for Denali, Roche Diagnostics, Wave, Samumed and CogRx, has given lectures in symposia sponsored by Fujirebio, Alzecure and Biogen, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures-based platform company at the University of Gothenburg, all unrelated to the work presented in this paper. GB has participated in meetings sponsored by, received speaker honoraria or travel funding from Biogen, Celgene, Merck, Novartis, Sanofi-Genzyme and Teva, and received honoraria for consulting Biogen, Roche and Teva. The other authors report no competing interests or any financial or personal relationships with organizations that could potentially be perceived as influencing the described research.