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Article History

Received: 2 June 2021

Accepted: 27 September 2021

First Online: 19 October 2021

Competing interests

: Research support was granted from Roche, Basel, Switzerland, especially with data collection and the decision to publish. Roche had no role and did not interfere in conceptualization or conduct of this study. N.D., C.S., and H.B. are salaried employees of Roche, Switzerland. P.M.M. and P.W.H. are consultants for Roche, Switzerland. The other authors of this paper declare no competing interests. Outside of the present study, the authors declare the following competing interests: P.M.M. is a consultant at Zeiss Forum and holds intellectual properties for machine learning and speckle-denoising. C.E. and A.T. received a financial grant from the National Institute for Health Research (NIHR) Biomedical Research Centre, based at Moorfields Eye Hospital, and also from the NHS Foundation Trust and the UCL Institute of Ophthalmology. The views expressed in this article are those of the authors and not necessarily those of the National Eye Institute, NHS, the NIHR, or the Department of Health. A.T. is a consultant for Heidelberg Engineering and Optovue and has received research grant funding from Novartis and Bayer. C.E. is a consultant for Heidelberg Engineering and has received research grant funding from Novartis.