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Article History

Received: 13 August 2021

Accepted: 19 December 2022

First Online: 5 January 2023

Competing interests

: AJV, PA, PL, PG, RS, ES, CP, AS and DRC are employees of nference and have financial interests in the company and in the successful application of this research. VS is an employee of nference and Anumana and has financial interests in these companies and in the successful application of this research. nference collaborates with bio-pharmaceutical, diagnostic, and medical device companies as well as with academic medical centers, health systems, and public health agencies on data science initiatives unrelated to this study. These collaborations had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. JCO receives personal fees from Elsevier and Bates College, and receives small grants from nference, Inc, outside the submitted work. ADB is supported by grants from NIAID (grants AI110173 and AI120698), Amfar (#109593), and Mayo Clinic (HH Shieck Khalifa Bib Zayed Al-Nahyan Named Professorship of Infectious Diseases). ADB is a paid consultant for Abbvie, Gilead, Freedom Tunnel, Pinetree therapeutics Primmune, Immunome, MarPam, Rion, Symbiosis, NexImmune and Flambeau Diagnostics, is a paid member of the DSMB for Corvus Pharmaceuticals, Equilium, CSL Behring, and Excision Biotherapeutics, has received fees for speaking for Reach MD, Peer Voice, and Medscape, owns equity for scientific advisory work in Tier 1 Bio, Zentalis, Rion, and Nference, and is founder and President of Splissen therapeutics, and member of the Board of Attivare. JCO received a grant from the MITrE corporation. JCO, JDY, BSP, APN, RTH, ADB and JH are employees of the Mayo Clinic. The Mayo Clinic may stand to gain financially from the successful outcome of the research. nference and Mayo Clinic have filed a provisional patent application associated with this study. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and is being conducted in compliance with Mayo Clinic Conflict of Interest policies.