Sato, Chihiro
Kawakami, Hisato
Tanaka, Ryo
Satake, Hironaga
Inoue, Kentaro
Kimura, Yutaka
Fujita, Junya
Kawabata, Ryohei
Chiba, Yasutaka
Satoh, Taroh
Nakagawa, Kazuhiko
Funding for this research was provided by:
Grant-in-Aid for Young Scientists from the Japan Society for the Promotion of Science (KAKENHI grant no. JP18K15330)
Article History
Received: 18 May 2023
Accepted: 28 June 2023
First Online: 4 July 2023
Competing interests
: H.K. has received consulting fees from Bristol-Myers Squibb Co. Ltd., Eli Lilly Japan K.K., MSD K.K., Ono Pharmaceutical Co. Ltd., Daiichi-Sankyo Co. Ltd., and Taiho Pharmaceutical Co. Ltd.; honoraria from Bristol-Myers Squibb Co. Ltd., AstraZeneca K.K., Bayer Yakuhin Ltd., Eli Lilly Japan K.K., MSD K.K., Ono Pharmaceutical Co. Ltd., Chugai Pharmaceutical Co. Ltd., Daiichi Sankyo Co. Ltd., Takeda Pharmaceutical Co. Ltd., and Taiho Pharmaceutical Co. Ltd.; lecture fees from Bristol-Myers Squibb Co. Ltd., Eli Lilly Japan K.K., MSD K.K., Ono Pharmaceutical Co. Ltd., Daiichi Sankyo Co. Ltd., Chugai Pharmaceutical Co. Ltd., Takeda Pharmaceutical Co. Ltd., and Taiho Pharmaceutical Co. Ltd.; and research funding from Bristol-Myers Squibb Co. Ltd., Chugai Pharmaceutical Co. Ltd., Taiho Pharmaceutical Co. Ltd., and Eisai Co. Ltd. H.S. has received honoraria from Bayer Co. Ltd., Bristol-Myers Squibb Co. Ltd., Chugai Pharmaceutical Co. Ltd., Daiichi Sankyo Co. Ltd., Eli Lilly Japan Co. Ltd., Merck Bio Pharma Co. Ltd., MSD Co. Ltd., Ono Pharmaceutical Co. Ltd., Sanofi Co. Ltd., Taiho Pharmaceutical Co. Ltd., Takeda Pharmaceutical Co. Ltd., and Yakult Honsha Co. Ltd., as well as research funding from Ono Pharmaceutical Co. Ltd., Daiichi Sankyo Co. Ltd., Taiho Pharmaceutical Co. Ltd., Takeda Pharmaceutical Co. Ltd., and Sanofi Co. Ltd. Y. K. reports grants and personal fees from Daiichi Sankyo Co. Ltd., outside the submitted work.T.S. reports grants, personal fees and other from Ono Pharmaceutial, grants and personal fees from Chugai Pharmaceutical, grants, personal fees and other from Yakult Honsha, grants and personal fees from Bristol-Myers, grants and personal fees from Elli-Lilly, grants and personal fees from Daiichi-sankyo, other from Takara-Bio, grants from Giliad, grants from BeiGene, grants from MSD, grants and other from Merck-BioPharm, grants and other from Taiho-Pharmaceutical, personal fees from Sanofi-Aventis, other from Takeda Pharmaceutical, outside the submitted work. K.N. reports grants and personal fees from AstraZeneca K.K., grants and personal fees from Astellas Pharma Inc., grants and personal fees from MSD K.K., grants, personal fees and other from Ono Pharmaceutical Co.,Ltd., grants and personal fees from Nippon Boehringer Ingelheim Co.,Ltd., grants and personal fees from Novartis Pharma K.K., grants, personal fees and other from Pfizer Japan Inc., grants and personal fees from Bristol Myers Squibb Company, grants, personal fees and other from Eli Lilly Japan K.K., grants and personal fees from Chugai Pharmaceutical Co.,Ltd., grants and personal fees from Daiichi Sankyo Co., Ltd., grants and personal fees from Merck Biopharma Co., Ltd., during the conduct of the study; personal fees from MEDICUS SHUPPAN,Publishers Co., Ltd., personal fees from Care Net, Inc, personal fees and other from KYORIN Pharmaceutical Co.,Ltd., personal fees from Medical Review Co., Ltd., personal fees from Roche Diagnostics K.K., personal fees from Medical Mobile Communications co., Ltd, personal fees from 3H Clinical Trial Inc., personal fees from Nichi-Iko Pharmaceutical Co., Ltd., grants, personal fees and other from Takeda Pharmaceutical Co.,Ltd., grants and personal fees from Taiho Pharmaceutical Co.,Ltd., grants from SymBio Pharmaceuticals Limited., personal fees from YODOSHA CO., LTD., personal fees from Nikkei Business Publications, Inc, personal fees from Thermo Fisher Scientific K.K., personal fees from YOMIURI TELECASTING CORPORATION., personal fees from Nippon Kayaku Co.,Ltd., grants and personal fees from AbbVie Inc, grants from ICON Japan K.K., grants from PAREXEL International Corp., grants from Kissei Pharmaceutical Co.,Ltd., grants from EPS Corporation., grants from Syneos Health., grants from Pfizer R&D Japan G.K., grants from A2 Healthcare Corp., grants from IQVIA Services JAPAN K.K., grants from Eisai Co., Ltd., grants from CMIC Shift Zero K.K., grants and personal fees from Kyowa Kirin Co.,Ltd, grants and personal fees from Bayer Yakuhin, Ltd, grants from EPS International Co.,Ltd,., grants from Otsuka Pharmaceutical Co., Ltd., personal fees from Hisamitsu Pharmaceutical Co.,Inc., personal fees from NANZANDO Co.,Ltd, personal fees from Amgen Inc., grants from PRA HEALTHSCIENCES, grants from Covance Japan Inc., grants from Medical Reserch Support, grants from Sanofi K.K., grants from PPD-SNBL K.K, grants from Japan Clinical Research Operations, grants from Sysmex Corporation, grants from AbbVie Inc., grants from Mochida Pharmaceutical Co., Ltd., grants from GlaxoSmithKline K.K., outside the submitted work. All remaining authors declare no conflict of interest.