Morgan, Ibrahim https://orcid.org/0000-0002-4032-2691
Rennert, Robert https://orcid.org/0000-0003-3665-6696
Berger, Robert https://orcid.org/0009-0000-9939-297X
Jelača, Sanja https://orcid.org/0000-0002-9848-6859
Maksimović-Ivanić, Danijela https://orcid.org/0000-0002-8006-5079
Dunđerović, Duško https://orcid.org/0000-0001-9708-2089
Mijatović, Sanja https://orcid.org/0000-0001-9509-9098
Kaluđerović, Goran N. https://orcid.org/0000-0001-5168-1000
Wessjohann, Ludger A. https://orcid.org/0000-0003-2060-8235
Funding for this research was provided by:
AIP e.V. funded by IB (state of Saxony-Anhalt) through EFRE (US2185, US2185)
Ministry of Science, Technological Development and Innovation of the Republic of Serbia (451-03-47/2023-01/ 200007, 451-03-47/2023-01/ 200007, 451-03-47/2023-01/ 200007)
Leibniz-Institut für Pflanzenbiochemie
Article History
Received: 23 April 2024
Accepted: 29 August 2024
First Online: 15 November 2024
Competing interests
: The authors declare no competing interests.
: The study was performed by using a syngeneic breast cancer model induced by orthotopic inoculation of 4T1 mouse breast cancer cells (TNBC) into inbred BALB/c mice. The in vivo mouse study was performed according to the guidelines of the European Union and in accordance with ARRIVE guidelines and approved by the Institutional Animal Care and Use Committee at the Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade (323-07-11755/2019-051). In that exploratory study, three groups were included, each comprising eight animals. The resulting total number of 24 animals aimed to avoid under- or overpowering of the study. The animals were kept under standard laboratory conditions with an ad libitum regime for food and water intake. The mice were assigned to the study groups using a stratified randomization approach, ensuring that the mean tumor volumes were as similar as possible across all groups.