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Authors
Cipriano, Gerson Jr
da Luz Goulart, Cássia
Chiappa, Gaspar R.
da Silva, Marianne Lucena
Silva, Natália Turri
do Vale Lira, Amanda Oliveira
Negrão, Edson Marcio
DÁvila, Luciana Bartolomei Orru
Ramalho, Sergio Henrique Rodolpho
de Souza, Fausto Stauffer Junqueira
Cipriano, Graziella França Bernardelli
Hirai, Daniel
Hansen, Dominique
Cahalin, Lawrence Patrick
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Article History
Received: 1 March 2024
Accepted: 12 September 2024
First Online: 28 September 2024
Declarations
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: The authors declare no competing interests.
: The kinetics of muscle microvascular deoxygenation are intricately associated with body composition, playing a pivotal role in exercise intolerance observed in HFpEF patients. Conversely, the central cardiovascular component predominates in determining exercise intolerance in HFrEF, indicating distinct pathophysiological mechanisms within heart failure subtypes.
: For patients with HFpEF, the interplay between skeletal muscle deoxygenation kinetics and body composition significantly influences exercise capacity. Interventions aimed at optimizing body composition—specifically reducing adipose tissue and enhancing lean muscle mass—hold promise for improving exercise tolerance in this population. Further research is needed to develop and evaluate targeted strategies that address these modifiable factors, potentially offering a novel therapeutic avenue to mitigate exercise intolerance in HFpEF.
