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Authors
Torralbo, Ana
Davitte, Jonathan M.
Croteau-Chonka, Damien C.
Ytsma, Cai
Tomlinson, Chris
Fitzpatrick, Natalie K.
Chung, Sheng-Chia
Fatemifar, Ghazaleh
Cortes, Adrian S.
Richardson, Tom G.
Barclay, Matthew
Carrasco-Zanini, Julia
Finan, Chris
Hemingway, Harry
Hingorani, Aroon D.
Kuan, Valerie
Langenberg, Claudia
Lyratzopoulos, Georgios
Lumbers, R. Thomas
Pietzner, Maik
Shah, Anoop D.
Thygesen, Johan H.
Zelenka, Natalie
Whittaker, John C.
Ehm, Margaret G.
Denaxas, Spiros
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Funding
Funding for this research was provided by:
GSK-UCL Phenomics Hub
NIHR-UKRI CONVALESCENCE
Health Data Research UK
UCL UKRI Centre for Doctoral Training in AI-enabled Healthcare studentship (EP/S021612/1)
MRC Clinical Top-Up, a studentship from the NIHR Biomedical Research Centre at University College London Hospital NHS Trust
American Heart Association
CRUK International Alliance for Cancer Early Detection (ACED) Pathway Award (EDDAPA-2022/100002)
National Institute for Health Research Biomedical Research Centre at University College Hospitals NHS Trust.
Cancer Research UK Advanced Clinician Scientist Fellowship (C18081/A18180)
the Rare Disease Research UK Platform: Cardiovascular Initiative, supported by the National Institute for Health Research
National Institutes of Health
UKRI Programme Grant (MC_UU_00002/18)
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Article History
Received: 14 April 2025
Accepted: 4 June 2025
First Online: 9 July 2025
Declarations
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: MGE, JCW, DCCC, ASC, TGR and JMD are employees and stakeholders of GlaxoSmithKline (GSK). JCW holds shares in GSK and was an employee of GSK until the end 2022. He has done extensive consultancy for pharma/biotech companies, with active agreements with Novo Nordisk, Relation Therapeutics Limited and Silence Therapeutics Plc. CT was employed at LifeArc, after manuscript preparation MB receives personal fees from GRAIL for membership of an Independent Data Monitoring Committee unrelated to this study. GF carried out work for this manuscript prior to starting as an employee at Novo Nordisk. The remaining authors have no conflict of interest.
