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Integrated bioinformatics and experimental validation identify lysosome and immune infiltration-related genes as therapeutic targets in late-onset major depressive disorder

Crossref DOI link: https://doi.org/10.1038/s41598-025-10283-9

Published Online: 2025-07-31

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hu, Jian-Zhen

Gao, Yao

Song, Xiao-Na

Wang, Dan

Du, Xin-Zhe

Wang, Xiao

Hu, Xiao-Dong

Liu, Sha
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Text and Data Mining valid from 2025-07-31

Version of Record valid from 2025-07-31
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Article History

Received: 28 November 2024

Accepted: 2 July 2025

First Online: 31 July 2025

Declarations

:

: This study, involving animal subjects, received ethical approval from the Experimental Animal Ethics Committee at the First Hospital of Shanxi Medical University (Approval No. DWYJ-2023-017). We ensured ethical conduct throughout the research by strictly following the “Guidelines for Ethical Review of Laboratory Animal Welfare.” Additionally, our study complied with the American Veterinary Medical Association Guidelines for Animal Euthanasia (2020) and the ARRIVE guidelines, which are instrumental in maintaining the integrity of our experimental design and the clarity of our results reporting.

: Not applicable.

: The authors declare no competing interests.

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