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Authors
Rahman, Muhammad Taifur
Mostaert, Brian J
Eckard, Peter
Fatima, Shakila Mahmuda
Scheperle, Rachel
Razu, Ibrahim
Hunger, Bryce
Olszewski, Rafal T.
Gu, Shoujun
Garcia, Cristina L.
Khan, Nashwaan Ali
Bennion, Douglas M
Oleson, Jacob
Kirk, Jonathon R.
Enke, Ya Lang
Gay, Robert D.
Morell, Robert J.
Hirose, Keiko
Hoa, Michael
Claussen, Alexander D.
Hansen, Marlan R.
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Funding
Funding for this research was provided by:
National Institute on Deafness and Other Communication Disorders (DC018488)
National Center for Advancing Translational Sciences (TR001013)
Cochlear
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Article History
Received: 30 January 2025
Accepted: 4 July 2025
First Online: 20 August 2025
Declarations
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: The authors decalre no competing interests.
: All animal experiments were approved by the University of Iowa Institutional Animal Care and Use Committee (IACUC), adhering to the Guide for the Care and Use of Laboratory Animals from the Institute for Laboratory Animal Research, National Research Council and is reported in accordance with ARRIVE guidelines. Male and female CX3CR1+/GFP Thy1+/YFP mice (n = 60) were used for this study, with macrophages and spiral ganglion neurons expressing eGFP and eYFP, respectively. Human studies were conducted following approval from the University of Iowa Institutional Review Board and performed in accordance with the Declaration of Helsinki (IRB; protocols 201805740, 202210440, 202307098). Written informed consent was obtained from all participants before enrollment in the study. Subjects underwent cochlear implantation using either investigational or FDA-approved devices, with procedures performed by a board-certified neurotologist. No photographs of patients were utilized in this study. The trial registration information can be found at “ClinicalTrials.gov”, with a registration no: NCT04750642. Registered 31 January 2021, .
: This study does not involve any personal data, including images, videos, or identifiable personal details. Written informed consent was obtained from all participants, and all authors have approved the publication of this article.
