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Article History

Received: 20 February 2024

Accepted: 8 July 2025

First Online: 29 July 2025

Declarations

:

: The authors declare no competing interests.

: No new sequence data or materials were generated. Results reported in this manuscript were after analysis of the following publicly available GEO DataSets: GSE49828 The DNA methylation landscape of human early embryos. GSE51239 DNA methylation dynamics of the human pre-implantation embryo. GSE76641 DNA Methylation Barcodes in Human Fetal Tissues and Human Induced Pluripotent Stem Cells. GSE76970 Reversion to naïve human pluripotency creates a new methylation landscape devoid of blastocyst or germline memory. GSE80970 Cortical hypermethylation across an extended region spanning the HOXA gene cluster on chromosome 7 is robustly associated with Alzheimer’s disease neuropathology. GSE110366 Profiling the DNA methylation pattern in naïve induced Pluripotent Stem cells and somatic cells. GSE120137 A multi-tissue full lifespan epigenetic clock for mice. GSE124708 Hyperandrogenemia and western-style diet act synergistically on transcription and DNA methylation in visceral adipose tissue of a non-human primate model. GSE129548 CGGBP1 regulates chromatin barrier activity and CTCF occupancy at repeats. GSE175195 TF ChIP-seq from HEK293. GSE175320 Histone ChIP-seq from HEK293. GSE200834 TNRC18 recognizes H3K9me3 to mediate transposable elements silencing at ERV regions. GSE200839 TNRC18 recognizes H3K9me3 to mediate transposable elements silencing at ERV regions. GSE233417 A comprehensive DNA methylation atlas for noncancer human tissue types. GSE247551 SPINDOC promotes genome-wide redistribution of Spindlin1. GSE109559 Cell type and species-specific methylation patterns in neuronal and non-neuronal cells of human and chimpanzee cortex. GSE53261 The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts.