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Article History

Received: 12 February 2025

Accepted: 29 July 2025

First Online: 24 October 2025

Declarations

:

: This study was approved by the Research Ethics Committee of the Affiliated Hospital of Binzhou Medical College. All study participants provided informed written consent before study enrollment(KYLL−112).

: The authors declare no competing interests.

: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

: Data may be shared at the request of anyqualified investigator for the purposes of replicating procedure and results.

: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.