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Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment

Crossref DOI link: https://doi.org/10.1038/s41598-025-15599-0

Published Online: 2025-08-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yamada, Yusei

Tanaka, Mayuko

Ikeda, Yusei

Kondo, Yuki

Takeo, Toru

Nakagata, Naomi

Miwa, Toru

Takeda, Hiroki

Orita, Yorihisa

Motoyama, Keiichi

Higashi, Taishi

Arima, Hidetoshi

Seki, Takahiro

Kurauchi, Yuki

Katsuki, Hiroshi

Higaki, Katsumi

Matsusaka, Kotaro

Minami, Kentaro

Yoshikawa, Naoki

Ikeda, Ryuji

Matsuo, Muneaki

Irie, Tetsumi

Ishitsuka, Yoichi
Funding

Funding for this research was provided by:

Japan Society for the Promotion of Science (21K15316, 21K06596, 20K07066)

Grant for Clinical Research from Miyazaki University Hospital

Clinical Research Support Grant from Miyazaki University Hospital
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Text and Data Mining valid from 2025-08-22

Version of Record valid from 2025-08-22
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Article History

Received: 21 April 2025

Accepted: 8 August 2025

First Online: 22 August 2025

Declarations

:

: The authors declare no competing interests.

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