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DDOX expands the repertoire of tetracyclines for Parkinson’s disease by preventing the cellular uptake and intracellular impact of α-synuclein preformed fibrils

Crossref DOI link: https://doi.org/10.1038/s41598-025-15991-w

Published Online: 2025-10-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Teran, María del Milagro

Tomas-Grau, Rodrigo Hernán

Soliz-Santander, Estefanía Silvana

Guayán, María Laura

Budeguer Isa, Valentina

Luna Mercado, Alvaro

Avila, Cesar Luis

Sosa-Padilla, Bernardo

Cruz, Hernán

Ciss, Ismaila

Besnault, Pierre

Socias, Sergio Benjamín

Vera Pingitore, Esteban

Ferrié, Laurent

Raisman-Vozari, Rita

Michel, Patrick Pierre

Figadère, Bruno

Chehín, Rosana Nieves

Ploper, Diego
Funding

Funding for this research was provided by:

Argentinean National Scientific and Technological Promotion Agency (PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417, PIP-CONICET 0183, PIP-CONICET 11220200102951, PICT-2021-CAT-I00166, PICT-2020-SERIEA-02706 and PICT-2020-SERIEA-02255 Raíces (III), PICT 2018-2989, PICT 2018-3379, PICT2019-04417)

Universidad Nacional de Tucumán (PIUNT D542/1, D644/1, and D759, PIUNT D542/1, D644/1, and D759, PIUNT D542/1, D644/1, and D759, PIUNT D542/1, D644/1, and D759)

Association France Parkinson (GAO 2018, DOXY- PARK, GAO 2018, DOXY- PARK, GAO 2018, DOXY- PARK, GAO 2018, DOXY- PARK, GAO 2018, DOXY- PARK, GAO 2018, DOXY- PARK)
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Text and Data Mining valid from 2025-10-29

Version of Record valid from 2025-10-29
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Article History

Received: 23 January 2025

Accepted: 12 August 2025

First Online: 29 October 2025

Competing interests

: L.F., P.P.M., R.R-V., and B.F. are listed as inventors on patent applications filed for the use of non-antibiotic tetracycline derivatives for the treatment of PD and related disorders. M.M.T, R.H.T-G, E.S.S-S, M.L.G., V.B.I., A.L.M., C.L.A., B.S-P., H.C., I.C., P.B., S.B.S., E.V.P., R.N.C. and D.P. declare no competing interests.

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