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N,N-Diethylacetamide and N,N-Dipropylacetamide inhibit the NF-kB pathway in in vitro, ex vivo and in vivo models of inflammation-induced preterm birth

Crossref DOI link: https://doi.org/10.1038/s41598-025-16076-4

Published Online: 2025-08-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Gorasiya, Samir

Mushi, Juliet

Yoganathan, Sabesan https://orcid.org/0000-0001-8033-3291
Barasa, Leonard

Pekson, Ryan https://orcid.org/0000-0002-1713-2582
Ashby, Charles R. Jr.

Reznik, Sandra E.
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Text and Data Mining valid from 2025-08-14

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Article History

Received: 17 October 2024

Accepted: 11 August 2025

First Online: 14 August 2025

Declarations

:

: CRA and SER have an allowed patent (US11717499B2) on the use of DMA, the parent compound, for the prevention of PTB. This work was funded by a grant from AMAG/Lumara Health.

: All animal care and experimental protocols were approved the St. John’s University Institutional Animal Care and Use Committee.

: Not applicable.

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