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Authors
Fedrizzi, Luca
Carugno, Michele
Consonni, Dario
Silibello, Camillo
Finardi, Sandro
Radice, Paola
Pesatori, Angela Cecilia
Landi, Maria Teresa
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Funding
Funding for this research was provided by:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, United States (Intramural Research Program)
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Article History
Received: 10 January 2025
Accepted: 21 August 2025
First Online: 27 August 2025
Declarations
:
: The authors declare no competing interests.
: The study was approved by the institutional review boards (IRBs) of the following institutions: USA: National Cancer Institute, Bethesda, MD; Italy: Università degli Studi di Milano, Milan; Istituti Clinici di Perfezionamento, Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan (now Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan); Ospedale Niguarda, Milan; Istituto Clinico Humanitas, Rozzano; Istituto Scientifico Universitario Ospedale San Raffaele, Milan; Ospedale Luigi Sacco, Milan; AO San Paolo, Milan; AO Ospedale San Carlo Borromeo, Milan; Ospedale Fatebenefratelli e Oftalmico, Milan; Ospedale San Giuseppe, Milan; Ospedale San Gerardo, Monza; Spedali Civili, Brescia; Fondazione IRCCS Policlinico San Matteo, Pavia; Ospedale di Circolo e Fondazione Macchi, Varese. The original IRB number was 02-C-N211. However, since the National Cancer Institute only received de-identified samples and data from collaborating centers, had no direct contact or interaction with the study participants, and did not use or generate identifiable private information, EAGLE has been later determined to constitute “Not Human Subject Research (NHSR)” based on the federal Common Rule (45 CFR 46; https://www.ecfr.gov/current/title-45/subtitle-A/subchapter-A/part-46).
