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Authors
Hark, Regina https://orcid.org/0009-0001-9211-5870
Zürlein, Simon
Nguyen, Viet T. https://orcid.org/0009-0003-3746-0123
Gust, Gunther https://orcid.org/0000-0001-6671-1380
Hekel, Lukas
Liedtke, Daniel https://orcid.org/0000-0003-0934-7169
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Funding
Funding for this research was provided by:
Julius-Maximilians-Universität Würzburg
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Article History
Received: 23 May 2025
Accepted: 5 September 2025
First Online: 17 September 2025
Declarations
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: All procedures involving experimental animals were performed in compliance with local animal welfare laws (Tierschutzgesetz §11, Abs. 1, Nr. 1 and corresponding TierSchVersV, husbandry permit number 568/300-1870/13), European Union animal welfare guidelines (EU directive 2010/63/EU), and best-practice scientific policies (ARRIVE guidelines). Establishment and propagation of alpl transgenic lines has been approved by the Regierung von Unterfranken (permit number 55.2.2-2532-2-1472). In addition, methods of adult genotyping by Fin-clip (55.2.2-2532-2-1637) and propagation of potential harmful transgenic lines (55.2.2-2532-2-1682) have been separately approved. No preselection on sex or other biological characteristics have been performed during the presented experiments. Experiments including early embryonic stages of development have been performed in zebrafish larvae younger than 120 hpf and have been terminated timely before free-swimming and independent feeding larval stages. Procedures involving transgenic animals were in addition performed according to local regulations on this topic (Gentechnikrecht/Gentechnik-Sicherheitsverordnung).
: The authors declare no competing interests.
