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Development and In Vivo evaluation of liposomal fentanyl nanocarriers using thin-film hydration and AI-based characterization for enhanced analgesic efficacy in anesthesia

Crossref DOI link: https://doi.org/10.1038/s41598-025-19683-3

Published Online: 2025-10-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zare-Zardini, Hadi

Saberian, Elham

Jenča, Andrej

Jenča, Andrej Jr

Petrášová, Adriána

Jenčová, Janka

Jarrahzadeh, Mohammad Hossein
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Text and Data Mining valid from 2025-10-14

Version of Record valid from 2025-10-14
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Article History

Received: 26 April 2025

Accepted: 10 September 2025

First Online: 14 October 2025

Declaration

:

: The authors declare that they have no competing interests.

: This study was approved by the Ethics Committee of Shahid Sadoughi University of Medical Sciences, Yazd, Iran, and was conducted in accordance with the ethical guidelines for the treatment of animals. All efforts were made to minimize animal suffering and reduce the number of animals used. This study is reported in compliance with the ARRIVE guidelines (), ensuring transparency and reproducibility in the reporting of in vivo experiments.

: All authors have consented to publication of this manuscript.

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