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Article History

Received: 28 January 2025

Accepted: 10 September 2025

First Online: 14 October 2025

Declarations

:

: S.B.R. serves as a consultant and scientific advisor to Myolex, Inc., a company that designs impedance devices for clinical and research use, including the one used in this study; he is also a member of the company’s Board of Directors and holds equity in the company. P.S., L.H., G.T., D.P., T.M., J.A.N., A.K.N declare no competing interests.

: We confirm that animal husbandry and experimental protocols were approved by the Institutional Animal Care and Use Committees at Beth Israel Deaconess Medical Center, in addition they adhere to the Guide for the Care and Use of Laboratory Animals (National Research Council), the provisions of the Animal Welfare Act (USDA), and the National Institute of Health (NIH)/Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals. This study was conducted as recommended by the ARRIVE guidelines. All procedures and analyses were randomized and blinded; the person performing the randomization was different from the one conducting the experiments and analyses. However, it should be noted that at the second time point (i.e., 40 weeks), ALS animals exhibited decreased weight as compared to healthy control animals. Therefore, we cannot assume that the experimenter was completely blinded to the experimental group while collecting the EIM and swimming data. However, the experimenter was blinded to the animal’s experimental group during the analysis of these datasets.