Crossmark

Design, synthesis, and biological evaluation of novel 6-(4-aminopiperidin-1-yl)-substituted benzyl-3-methylpyrimidine-2,4(1H,3H)-dione derivatives as potential anticancer agents targeting thymidylate synthase

Crossref DOI link: https://doi.org/10.1038/s41598-025-24828-5

Published Online: 2025-11-20

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Baziar, Ladan

Ataollahi, Elaheh

Rezaei, Zahra

Abdulkadhim, Yousif

Abdolahi, Mohammad Reza

Poustforoosh, Alireza

Zare, Somayeh

Emami, Mina

Mansouri, Maryam Moghtader

Emami, Leila

Khabnadideh, Soghra
Funding

Funding for this research was provided by:

Shiraz Transplant Research Center, Shiraz University of Medical Sciences (30102)
License Information

Text and Data Mining valid from 2025-11-20

Version of Record valid from 2025-11-20
More Information

Article History

Received: 3 August 2025

Accepted: 15 October 2025

First Online: 20 November 2025

Declarations

:

: The authors declare no competing interests.

: The authors declare no conflict of interest.

Document is current

Any future updates will be listed below