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Pro‑inflammatory insulin‑resistant lipid phenotype in down syndrome identified by 1H‑NMR metabolomics in obesity-matched African‑American children and young adults

Crossref DOI link: https://doi.org/10.1038/s41598-025-26217-4

Published Online: 2025-11-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Qu, Hui-Qi

Connolly, John J.

Eister, Garnet

Mentch, Frank

Glessner, Joseph

Hakonarson, Hakon
Funding

Funding for this research was provided by:

The International Hundred Thousand Plus Cohort Consortium

Children’s Hospital of Philadelphia
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Text and Data Mining valid from 2025-11-26

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Article History

Received: 20 May 2025

Accepted: 27 October 2025

First Online: 26 November 2025

Declarations

:

: The authors declare no competing interests

: This study was approved by the Institutional Review Board (IRB) of the Children’s Hospital of Philadelphia and conducted in accordance with the Declaration of Helsinki, the U.S. Common Rule (45 CFR 46), and all applicable institutional guidelines for pediatric and vulnerable populations. Human participants and personal information are all encrypted to ensure no PHI are included and study participants are de-identified. All human subjects or their proxies provided written informed consent.

: All authors have provided consent for publication of the manuscript.

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