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Authors
Jin, Hanqiang
Chen, Ruoyu
Wang, Yonggang
Huang, Jin
Cao, Xue-ping
Raza, Hafiz Khuram
Fang, Xian-long
Zhang, Kang-jian
Li, Ning
Zhou, Shumin
Yang, Qingcheng
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Funding
Funding for this research was provided by:
Shanghai Oriental Talent Program (CYQN2023030)
Academician Expert Workstation Grants in Shanghai Yuansong Biotechnology Co. (19R1002275468, 20R9004076411, 21R4007547098, S182023110190129357)
Shanghai science and technology support project on biomedicine in the action plan of Science and Technology innovation (19431904200)
National Natural Science Foundation of China (82173343)
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Article History
Received: 20 March 2025
Accepted: 31 October 2025
First Online: 10 December 2025
Competing interests
: Kang-jian Zhang and Xian-long Fang hold an ownership interest (including patents of YSCH-01) in Yuansong Biotechnology. Other authors report no conflict of interest.
: The protocol of the human tumor tissues study was approved by the Ethics Committee of Shanghai Sixth People’s Hospital (NO. 2020 − 131). All methods were carried out in accordance with relevant guidelines and regulations. We followed the ethical guidelines outlined in the Helsinki Declaration for conducting research involving human subjects. We guaranteed the protection of data anonymity and confidentiality and utilizing it solely for purposes stated above. Informed consent was obtained from all subjects and/or their legal guardian(s).
: All animal experimental protocols were approved by the Experimental Animal Care Commission of Shanghai LIDE biotech Co. Ltd (the reference number LDIACUC 006). All methods of animal study were carried out in accordance with relevant guidelines and regulations. This study is reported in accordance with the ARRIVE guidelines. Mice were monitored every other day for humane endpoints, specifically tumor size, activity levels, and weight loss exceeding 15%. At the time of sacrifice, none of the animals had reached these humane endpoints. The mice were euthanized in a CO₂ environment via cervical dislocation.
