Sawamura, Daisuke https://orcid.org/0000-0003-3180-3474
Duan, Miaowen
Inagaki, Yuji
Saito, Ryuji
Okada, Kazufumi
Watanabe, Akihiro
Tohyama, Harukazu
Maeyama, Takaya
Yoshida, Susumu
Miyazaki, Mitsunori
Hasegawa, Naoya
Yokosawa, Koichi
Ono, Yumie
Funding for this research was provided by:
Japan Society for the Promotion of Science (22K1144202)
Japan Society for the Promotion of Science (23H00459)
Article History
Received: 5 June 2025
Accepted: 10 November 2025
First Online: 12 December 2025
Declarations
:
: The authors declare no competing interests.
: All participants provided written informed consent before inclusion in the study and received financial compensation. The study was conducted in accordance with the Declaration of Helsinki and Consolidated Standards of Reporting Trials guidelines. This study was approved by the Institutional Review Board of the Faculty of Health Sciences at Hokkaido University (approval number: 23–71) and prospectively registered on 09/13/2023 in the University Hospital Medical Information Network Clinical Trial Registry in Japan (UMIN000052202).