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Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata)

Crossref DOI link: https://doi.org/10.1038/s41598-025-28793-x

Published Online: 2025-11-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Graser, Leonie

Gordon, Eric RL

Jamison, Matthew

Talton, Win

Chen, Yuting

Knorr, Eileen

Windfelder, Anton

Narva, Kenneth

Vilcinskas, Andreas
Funding

Funding for this research was provided by:

Justus-Liebig-Universität Gießen
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Text and Data Mining valid from 2025-11-21

Version of Record valid from 2025-11-21
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Article History

Received: 28 July 2025

Accepted: 12 November 2025

First Online: 21 November 2025

Declarations

:

: EG, MJ, WT, YC, and KN are employed by the company GreenLight Biosciences, Inc., the developer and manufacturer of ledprona and Calantha ® and owner of patents covering the same, including, for example, U.S. Patent No. 11,142,768. EK, AW, and AV are employed by Fraunhofer Institute for Molecular Biology and Applied Ecology. LG is employed by the Justus Liebig University Giessen and the Fraunhofer Institute for Molecular Biology and Applied Ecology.

: Supporting Information is available from the Wiley Online Library or from the author.

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