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Article History

Received: 27 February 2025

Accepted: 19 November 2025

First Online: 30 November 2025

Declarations

:

: The authors declare no competing interests.

: This study was conducted in compliance with all relevant institutional and national guidelines and regulations. All experimental procedures involving human tissue samples were reviewed and approved by the Ethics Committee of Kyushu University (approval number: 22002-00). For the use of FFPE samples, the requirement for written informed consent was waived by the Ethics Committee, as relevant study information was made publicly available on the university’s official website, including contact information for individuals wishing to opt out. All animal experiments were designed, conducted, and reported in accordance with the ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments). These experiments were further carried out in accordance with the Guidelines for Animal Experiments of Kyushu University and were approved by both the Ethics Committee and the Institutional Animal Care and Use Committee of Kyushu University (approval number: A24-006-0).