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Disulfiram inhibits Gasdermin D pores formation and improves insulin-dependent glucose uptake and glucose homeostasis in skeletal muscle of obesity-induced insulin-resistant mice

Crossref DOI link: https://doi.org/10.1038/s41598-025-30058-6

Published Online: 2025-11-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Cadagan, Cynthia

Russell-Guzmán, Javier

Américo-Da-Silva, Luan

Montaña, Paula

Barrientos, Genaro

Buvinic, Sonja

Tapia, Gladys

Estrada, Manuel

Llanos, Paola
Funding

Funding for this research was provided by:

Agencia Nacional de Investigación y Desarrollo (FONDECYT 1241661)

Agencia Nacional de Investigación y Desarrollo (FONDECYT 1231103)
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Text and Data Mining valid from 2025-11-26

Version of Record valid from 2025-12-30
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Article History

Received: 14 July 2025

Accepted: 20 November 2025

First Online: 26 November 2025

Declarations

:

: The authors declare no competing interests.

: All animal experiments were approved by the Animal Bioethics Committee of the Faculty of Dentistry, University of Chile (Protocol CBA 240423 FOUCH).

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