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Article History

Received: 20 August 2024

Accepted: 10 December 2025

First Online: 11 December 2025

Declarations

:

: The authors declare no competing interests.

: This study was approved by the Research Ethics Committee of the Principality of Asturias, serving as the reference committee, and was accepted by the ethics committees of the other participating centers. It was classified as observational and approved by the Spanish Agency of Medicines and Medical Devices (AEMPS) (identification code: L34LM-MM2GH-Y925U-RJDHQ). The acceptance date of the 15 centers and clinical research ethics committees was (1) Hospital Universitario de Canarias, Tenerife (20 June 2020); (2) Hospital Universitario La Paz, Madrid (4 March 2020); (3) Hospital Universitario Central de Asturias, Oviedo (17 May 2019)—reference committee; (4) Complejo Hospitalario Universitario de Ourense, Orense (7 January 2020); (5) Hospital Universitario Infanta Leonor, Madrid (15 May 2020); (6) Consorcio Hospital General Universitario de Valencia, Valencia (4 September 2020); (7) Hospital General Virgen de la Luz, Cuenca (10 March 2020); (8) Hospital Provincial de Castellón, Castellón (23 July 2020); (9) Hospital General Universitario de Elche, Elche (20 March 2020); (10) Hospital Universitario Clínico San Carlos, Madrid (19 January 2020); (11) Hospital San Pedro de Alcántara, Cáceres (26 June 2020); (12) Hospital Universitario Morales Meseguer, Murcia (8 July 2020); (13) Hospital Quironsalud Sagrado Corazón, Sevilla (13 February 2020); (14) Hospital General Universitario Santa Lucia, Cartagena (14 October 2020); (15) Hospital General Universitario de Ciudad Real, Ciudad Real (18 November 2020). This study was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments. This study was an observational, non-interventionist trial. Signed informed consent was obtained from all patients.