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Authors
Vardon, Ashley
Haston, Scott
Hamdi, Hiba
Cooksley, Grace
Guiho, Romain
Carvalho, Diana
Carter, Rebecca
Boult, Jessica Katherine Rowena
Gharai, Daniel
Cloete, Ielyaas
Grey, James
Apps, John
Zhou, Daohong
Zheng, Guangrong
Martínez-Máñez, Ramón
Lythgoe, Mark Francis
Donovan, Laura Kate
Carcaboso, Angel Montero
Williams, Owen
Hong, Ying
Alexandre, Paula
Gil, Jesus
Dean, Jamie Adam
Michod, David
Jones, Chris
Hargrave, Darren
Martinez-Barbera, Juan-Pedro
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Funding
Funding for this research was provided by:
Cancer Research UK (C7893/A28990)
Cancer Research UK (C54322/A27725)
Cancer Research UK (RRNPSF-Mar22\100002)
Cancer Research UK (C15075/A28647)
Cancer Research UK (C7893/A28990).)
Cancer Research UK (DRCRPG-Nov21\100002)
Cancer Research UK (C54322/A27727)
Medical Research Scotland (MC_U120085810)
Brain Tumour Research (DRCRPG-Nov21\100002)
Brain Tumour Charity (GN-000382, GN-000707, GN-000522 and GN-000728)
Great Ormond Street Hospital Charity (V5119)
NIHR Great Ormond Street Hospital Biomedical Research Centre
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Article History
Received: 20 March 2025
Accepted: 11 December 2025
First Online: 22 December 2025
Declarations
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: J.G. has acted as a consultant for Unity Biotechnology, Geras Bio, Myricx Pharma, and Merck KGaA. Pfizer and Unity Biotechnology have funded research in J.G.’s lab (unrelated to the work presented here). J.G. owns equity in Geras Bio. J.G. is a named inventor in MRC and Imperial College patents, both related to senolytic therapies (the patents are not related to the work presented here). The other authors have no conflict of interest to declare.
