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Mechanisms of FOXK1-regulated glycolipid metabolism in mediating TOX-induced histone lactylation to promote CD8⁺ T cell exhaustion in high-grade serous ovarian cancer

Crossref DOI link: https://doi.org/10.1038/s41598-025-32938-3

Published Online: 2026-02-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Li, Min
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Text and Data Mining valid from 2026-02-03

Version of Record valid from 2026-02-09
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Article History

Received: 13 August 2025

Accepted: 15 December 2025

First Online: 3 February 2026

Declarations

:

: The authors declare no competing interests.

: All animal experiments were conducted humanely and in strict accordance with approved protocols under the oversight of the Institutional Animal Care and Use Committee (IACUC) of Guangdong Laidi Biomedical Research Institute Co., Ltd (Approval number: LDSW2025027-3). All procedures complied with the ethical standards of animal experimentation and followed the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines to ensure the welfare, transparency, and reproducibility of the research. Consent to Participate, and Consent to Publish declarations are not applicable.

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