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Authors
Wu, Yanan
Ge, Yanlei
Gan, Junqing
Jin, Ye
Cui, Yishuang
Zheng, Xuan
Yao, Xuemin
Sun, Guogui
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Funding
Funding for this research was provided by:
Natural Science Foundation of Hebei Province (H2023209083)
Hebei Provincial Department of Science and Technology (235A2403D)
Department of Education of Hebei Province (JZX2024009)
High level Research and Innovation Team Construction Plan of School of Public Health, North China University of Science and Technology (KYTD202309)
Tangshan Science and Technology Bureau (24150218C)
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Article History
Received: 8 October 2024
Accepted: 25 February 2025
First Online: 18 March 2025
Declarations
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: The authors declare no competing interests.
: Tissues and blood samples used in the current study were obtained from Tangshan People’s Hospital. Specifically, patients were admitted to the Pathology Department of Tangshan People’s Hospital between December 2021 and December 2023. Patients diagnosed with LUAD were enrolled. All patients were diagnosed based on histological examination results. Patients with active systemic infections or autoimmune diseases were excluded. The cancer tissues and adjacent normal tissues used in the current study were then obtained during intraoperative. The paracancerous tissues, located more than 5.0 cm away from the tumor, were confirmed as normal controls through H&E stains. Healthy donors were recruited as healthy controls from the physical examination center of Tangshan People’s Hospital. All experiments involving human tissues were approved by the Ethics Committee of Tangshan People’s Hospital (Approval No.: RMYY-LLKS-2021-103, Approval date: 13 December 2021) and performed in accordance with the Declaration of Helsinki. All methods were carried out with approved protocols, relevant guidelines and regulations. Informed consents were obtained from all participants in the current study.
