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Authors
McVey, John C.
Wattenberg, Max M.
Coho, Heather
Infante, Kayjana
Markowitz, Kelly
Delman, Devora
Clendenin, Cynthia
Furth, Emma E.
Tondon, Rashmi
Stanger, Ben Z.
Vonderheide, Robert H.
Reiss, Kim A.
Beatty, Gregory L.
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Funding
Funding for this research was provided by:
National Institutes of Health (T32-CA251063)
National Institutes of Health (K12-CA076931-21)
National Institutes of Health (P30-CA016520)
National Institutes of Health (R01-CA197916)
Damon Runyon Cancer Research Foundation (PST-34-21)
U.S. Department of Defense (W81XWH2210730)
A Love for Life
Penn Pancreatic Cancer Research Center
Basser Center for BRCA
Parker Institute for Cancer Immunotherapy
Konner Fund
Basser Center Young Leadership Award
Philip and Pearl Basser Award
anonymous foundation
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Article History
Received: 8 June 2025
Accepted: 6 January 2026
First Online: 31 January 2026
Declarations
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: The authors declare no competing interests.
: M.M.W. reports prior or active roles as a consultant for Rondo Therapeutics and Nanology. B.Z.S. receives research funding from Boehringer-Ingelheim and Revolution Medicines and holds equity in iTeos Therapeutics. R.H.V has received consulting fees from BMS, EMD Serono, Grey Wolf Therapeutics and Crossbow Therapeutics, research funding form Revolution Medicines, is an inventor on patents relating to cancer cellular immunotherapy, cancer vaccines, and KRAS immune epitopes, and receives royalties form Children’s Hospital Boston for a licensed research-only monoclonal antibody. G.L.B. reports active roles as consultant/advisory board member for Hibercell, Pancreatic Cancer Action Network, EMD Serono and Alligator Biosciences; reports receiving active research funding from Alligator Biosciences, Incyte Corporation and Bristol-Myers Squibb; and is an inventor of intellectual property related to CAR T cells.
: All data supporting the findings of this study are included in the paper and its Supplementary Information. RNAseq data have been deposited at the Gene Expression Omnibus (GEO) under accession numbers GSE300887 and GSE300888. Additional data are available from the corresponding author upon reasonable request.
