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Mitochondrial dysfunction and Ca2+ dysregulation in human iPSC-derived neurons carrying presenilin-1 mutation arise under stress via an MCU-1-independent mechanism

Crossref DOI link: https://doi.org/10.1038/s41598-026-35597-0

Published Online: 2026-01-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wilson, Carlos

Galeano, Pablo

Remedi, María Mónica

Novack, Gisela Vanina

Campanelli, Lorenzo

Gastaldi, Laura

Miglietta, Esteban

Rossi, Andres Hugo

Olivar, Natividad

Brusco, Luis Ignacio

Castaño, Eduardo Miguel

Cáceres, Alfredo

Morelli, Laura https://orcid.org/0000-0001-5759-1807
Funding

Funding for this research was provided by:

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (PICT-2015-0285 and PICT-2016-4647)

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (PIBT/09-2013)

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (PIBT/09-2013, PICT-2015-0285 and PICT-2016-4647)

Alzheimer Argentina

Fundacion Ciencias Biomedicas Cordoba
License Information

Text and Data Mining valid from 2026-01-22

Accepted Manuscript valid from 2026-01-22
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Article History

Received: 30 October 2025

Accepted: 7 January 2026

First Online: 22 January 2026

Declarations

:

: The authors declare no competing interests.

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