Document is current

Article History

Received: 22 August 2025

Accepted: 9 January 2026

First Online: 30 January 2026

Declarations

:

: Jennifer Willingham-Lane, Christine Henderson, and John Harrington are employees of Boehringer Ingelheim Animal Health, USA Inc. All remaining authors have no competing interests.

: All procedures and experiments involving mice were performed in accordance with the ethical and regulatory standards established by the NIH for animal experimentation. The study was approved under animal use protocol 00136 by the Thomas Jefferson University Institutional Animal Care and Use Committee (IACUC). Studies performed at the University of Pennsylvania were approved under protocol 805059 by the University IACUC. These protocols comply with the guidelines outlined in the Guide for the Care and Use of Laboratory Animals by the National Research Council of the USA. Study design, methods, analysis and reporting were conducted in alignment with the ARRIVE guidelines.