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From in-silico QSAR modeling to in-vitro MTT assay: experimental validation of novel uPAR leads for triple-negative breast cancer (TNBC) and skin cancer

Crossref DOI link: https://doi.org/10.1038/s41598-026-36406-4

Published Online: 2026-01-20

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Badukle, Harshal

Jawarkar, Rahul D.

Shah, Umang

Chaudhary, Somdutta

Alzahrani, Abdullah Yahya Abdullah

Samad, Abdul

Al-Hussain, Sami A.

Al-Mutairi, Aamal A.

Zaki, Magdi E.A.
Funding

Funding for this research was provided by:

This work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (MSIU-DDRSP2601))
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Text and Data Mining valid from 2026-01-20

Version of Record valid from 2026-02-11
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Article History

Received: 5 October 2025

Accepted: 13 January 2026

First Online: 20 January 2026

Declarations

:

: The authors declare no competing interests.

: The MMT assay was carried out at Department of Pharmaceutical Chemistry, Ramanbhai Patel College of Pharmacy, CHARUSAT Campus, Changa, Gujarat 388421. The source of cell line used in the study were procured from the National Center for Cell Science, Pune.

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