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PERK inhibition attenuates multi-program cell death through Nrf2/HO-1 activation in diabetic retinopathy with integrated proteomics and functional validation in HRECs

Crossref DOI link: https://doi.org/10.1038/s41598-026-38213-3

Published Online: 2026-02-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Xie, Like

Zhang, Xinran

Tian, Min

Tang, Min

Zhou, Qi

Lv, Hongbin
Funding

Funding for this research was provided by:

Sichuan Provincial Science and Technology Support Program (2024ZYD0114)

Sichuan Provincial Science and Technology Support Program (2024ZYD0114)

Sichuan Provincial Science and Technology Support Program (2024ZYD0114)

Sichuan Provincial Science and Technology Support Program (2024ZYD0114)

Sichuan Provincial Science and Technology Support Program (2024ZYD0114)

Sichuan Provincial Science and Technology Support Program (2024ZYD0114)

Sichuan Medical Association (S2024001)

Sichuan Medical Association (S2024001)

Sichuan Medical Association (S2024001)

Sichuan Medical Association (S2024001)

Sichuan Medical Association (S2024001)

Sichuan Medical Association (S2024001)

Sichuan Association of Integrated Traditional Chinese and Western Medicine (ZXY2025017)

Sichuan Association of Integrated Traditional Chinese and Western Medicine (ZXY2025017)

Sichuan Association of Integrated Traditional Chinese and Western Medicine (ZXY2025017)

Sichuan Association of Integrated Traditional Chinese and Western Medicine (ZXY2025017)

Sichuan Association of Integrated Traditional Chinese and Western Medicine (ZXY2025017)

Sichuan Association of Integrated Traditional Chinese and Western Medicine (ZXY2025017)
License Information

Text and Data Mining valid from 2026-02-04

Accepted Manuscript valid from 2026-02-04
More Information

Article History

Received: 9 August 2025

Accepted: 29 January 2026

First Online: 4 February 2026

Declarations

:

: The authors declare no competing interests.

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