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Article History

Received: 14 August 2025

Accepted: 3 February 2026

First Online: 13 April 2026

Declarations

:

: The authors declare no competing interests.

: Informed consent was obtained from each patient and the study was carried out in accordance with the relevant guidelines and regulations effective for the participating study centers. Specifically, ethical review and approval of health-related research studies which are not clinical trials of medicinal products for human use as defined in SI 190/2004 was undertaken by the Research Ethics Committee of Beaumont Hospital, RCSI Hospital Group in Ireland. The study was approved by the Medical Ethics Commission of the Faculty of Medicine in Mannheim, Heidelberg University in Germany. The collection, storage, and use of archival tissue and patient data were performed in compliance with the Code for Proper Secondary Use of Human Tissue in The Netherlands (2011), developed by the standing committee of the FEDERA (FMWV Foundation, Chamber of Commerce, Rotterdam, 41055219,   and  ) and the Commissie Regelgeving in Onderzoek (COREON), in close cooperation with BBMRI-NL and patient organisations.

: During the preparation of this work, the authors used ChatGPT to query for additional information, improve the readability and language of the manuscript. After using this tool/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the published article.