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Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery

Crossref DOI link: https://doi.org/10.1038/s41598-026-40196-0

Published Online: 2026-02-27

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Sinderewicz, Emilia

Dąbkowska, Maria

Sarnowska, Anna

Staszkiewicz-Chodor, Joanna

Mystkowska, Dorota

Holak, Piotr

Drozd, Igor

Chodkowska-Michalowska, Magdalena

Rytel, Monika

Paczkowska, Edyta

Mycko, Marcin P.

Machalinski, Boguslaw

Jezierska-Wozniak, Katarzyna
Funding

Funding for this research was provided by:

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)

Medical Research Agency, Poland (No: 2020/ABM/01/00014-00)
License Information

Text and Data Mining valid from 2026-02-27

Version of Record valid from 2026-04-02
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Article History

Received: 17 September 2025

Accepted: 11 February 2026

First Online: 27 February 2026

Declarations

:

: The authors declare no competing interests.

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