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Pancreatitis-associated chymotrypsin C (CTRC) variant p.R240Q selectively impairs trypsinogen degradation through disruption of long-range electrostatic interactions

Crossref DOI link: https://doi.org/10.1038/s41598-026-40633-0

Published Online: 2026-02-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Nagy, Zoltán Attila

Sándor, Máté

Hegyi, Eszter

Juríček, Radovan

Hrčková, Gabriela

Sahin-Tóth, Miklós
Funding

Funding for this research was provided by:

National Research, Development and Innovation Office of Hungary (FK 143444)

János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00824/23/5)

National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK082412)
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Text and Data Mining valid from 2026-02-24

Version of Record valid from 2026-03-13
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Article History

Received: 11 January 2026

Accepted: 13 February 2026

First Online: 24 February 2026

Declarations

:

: The authors declare no competing interests.

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