Chen, Shuai-Jun
Cui, Xiao-Lin
Li, Qian
Xiao, Ling-Yan
Rao, Shan-Shan
Lu, Yu-zhi
Zhang, Hong-Feng
Funding for this research was provided by:
Wuhan Science and Technology Bureau (N0. 2024040801020368)
National Natural Science Foundation of China (No. 110075)
Wuhan Municipal Health Commission (No. WX23Z19)
Article History
Received: 3 November 2025
Accepted: 16 February 2026
First Online: 23 February 2026
Competing interests
: The authors declare no competing interests.
: This study was approved by the Medical Ethics Review Board of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Approval No. TJ-IRB20210222). All procedures involving human participants adhered to the Declaration of Helsinki, and written informed consent was obtained from every patient. Furthermore, all animal experimental protocols were approved by the Institutional Animal Care and Use Committee of Tongji Medical College, Huazhong University of Science and Technology (Approval No. 3509). All animal experiments were performed in accordance with the relevant guidelines and regulations, specifically complying with the ARRIVE guidelines (https://arriveguidelines.org).