Crossmark

Integrative analysis of single-cell RNA sequencing, bulk RNA sequencing, and proteomic data identified NOTCH3 as a hub gene contributing to human intervertebral disc fibrosis

Crossref DOI link: https://doi.org/10.1038/s41598-026-40696-z

Published Online: 2026-02-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ding, Qi

Chen, Xi

Zheng, Quan

Dou, Qiangbing

Zuo, Chuanhong

Wang, Qiwei

Shen, Cailiang
Funding

Funding for this research was provided by:

National Key Clinical Specialty Construction Projects of China.
License Information

Text and Data Mining valid from 2026-02-26

Version of Record valid from 2026-04-02
More Information

Article History

Received: 11 October 2025

Accepted: 16 February 2026

First Online: 26 February 2026

Declarations

:

: This study was performed in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Anhui Medical University (Approval No. 20210436). Written informed consent was obtained from all individual participants included in the study.

: The authors declare no competing interests.

Document is current

Any future updates will be listed below